CMAUP Plant Collective Molecular Activities

Plant Name: Bassia scoparia

Taxonomic Information:

Plant ID: NPO21107
Plant Latin Name: Bassia scoparia
Taxonomy Genus: Bassia
Taxonomy Family: Chenopodiaceae

Plant External Links:

NCBI TaxonomyDB: 83154
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Antibacterial; Antifungal; Antiphlogistic; Astringent; Cardiotonic; Diuretic; Skin

Geographical Distribution:

India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; AKR1B10; POLB;
Protein Kinase	EGFR;
Lyase	CA2; CA14; CA5A; CA6; CA12; CA1; CA9; CA7;
Nuclear hormone receptor subfamily 1 group H	NR1H4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.117E-09	1.722E-05	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, NR1H4, PTPN1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	2.644E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.186E-06	2.644E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.186E-06	2.644E-03	GPBAR1, NR1H4
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	4.370E-06	4.531E-03	EGFR, PLA2G1B
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.370E-06	4.531E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.017E-05	9.140E-03	NR1H4, PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	9.140E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.250E-22	7.077E-18	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.844E-18	6.419E-14	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.058E-16	3.509E-12	CA1, CA12, CA2, CA5A, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.615E-05	1.783E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.287E-22	5.480E-20	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.772E-03	3.485E-02	PTPN1, EGFR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.633E-03	3.485E-02	CA2, NR1H4
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	2.959E-03	4.364E-02	CA2, PLA2G1B
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.559E-02	1.089E-01	PLA2G1B, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.941E-02	1.089E-01	EGFR, CDC25B
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.271E-02	1.089E-01	CA2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.438E-02	1.089E-01	PLA2G1B
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2.687E-02	1.089E-01	AKR1B10
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	2.769E-02	1.089E-01	POLB

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases