CMAUP Plant Collective Molecular Activities

Plant Name: Bassia scoparia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.117E-09	1.722E-05	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, NR1H4, PTPN1
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	1.157E-06	1.939E-03	CA2, CA7, EGFR, NR1H4, PLA2G1B
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	2.644E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.186E-06	2.644E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.186E-06	2.644E-03	GPBAR1, NR1H4
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	4.370E-06	4.531E-03	EGFR, PLA2G1B
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.370E-06	4.531E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.017E-05	9.140E-03	NR1H4, PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	9.140E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.250E-22	7.077E-18	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.844E-18	6.419E-14	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.058E-16	3.509E-12	CA1, CA12, CA2, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	9.287E-22	5.480E-20	CA12; CA1; CA2; CA5A; CA7; CA6; CA9; CA14
hsa04520	Adherens junction_Homo sapiens_hsa04520	1.772E-03	3.485E-02	PTPN1; EGFR
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.633E-03	3.485E-02	CA2; NR1H4
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	2.959E-03	4.364E-02	CA2; PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Prostate cancer	C61	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	EGFR; EGFR
C00-D49: Neoplasms	Renal cancer	C64	CA9
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Glioma	C71	EGFR; EGFR
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; EGFR
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR; EGFR
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	EGFR; EGFR; EGFR
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
C00-D49: Neoplasms	Colon cancer	C50	EGFR
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; EGFR
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR
C00-D49: Neoplasms	Melanoma	C43	EGFR
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR
C00-D49: Neoplasms	Urethral cancer	NA	EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CDC25B; CA9; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; EGFR
C00-D49: Neoplasms	Breast cancer	C50	CA9; EGFR; EGFR; EGFR
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Bladder cancer	C67	EGFR
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; EGFR
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	EGFR; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; EGFR

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases