CMAUP Plant Collective Molecular Activities

Plant Name: Angelica keiskei

Taxonomic Information:

Plant ID: NPO21056
Plant Latin Name: Angelica keiskei
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 357850
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; China

Traditional Medicine System:

TCM

Geographical Distribution:

Indonesia; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRK1;
Hydrolase	GAA;
Enzyme_unclassified	TDP1; P4HB; AKR1B1; ALDH1A1; SENP6; SENP7; SENP8; POLB;
Protein Kinase	MAPK1;
Lyase	CA2; CA12; CA7; CA4;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP12; MMP2;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP2C19; CYP3A4; CYP1A2; CYP2A6; CYP2A13; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	SENP6	Sentrin-specific protease 6	Q9GZR1	CHEMBL1741215
Enzyme_unclassified	SENP7	Sentrin-specific protease 7	Q9BQF6	CHEMBL1741213
Enzyme_unclassified	SENP8	Sentrin-specific protease 8	Q96LD8	CHEMBL1741207
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRK1	Kappa opioid receptor	P41145	CHEMBL237
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.178E-14	6.920E-10	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.169E-12	3.535E-08	CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.613E-12	4.689E-08	CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.158E-11	1.935E-07	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.061E-10	2.889E-07	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	6.575E-10	1.193E-06	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.011E-09	2.919E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.141E-09	4.023E-06	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.528E-09	6.335E-06	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	9.618E-09	8.726E-06	CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.216E-08	9.455E-06	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.574E-08	1.142E-05	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.556E-08	2.347E-05	CYP1A2, CYP2A13, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.305E-08	4.038E-05	AKR1B1, CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.061E-07	5.922E-05	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.334E-07	1.271E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.625E-07	1.880E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.335E-07	2.640E-04	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	2.176E-06	9.873E-04	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	6.523E-06	2.785E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	2.785E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	1.329E-05	5.361E-03	CYP1A2, MAPK1, MMP9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.857E-05	7.135E-03	CA12, CA2, CA4, CA7, L3MBTL1, MMP12, MMP2, MMP9
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.366E-04	4.508E-02	AKR1B1, MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.024E-10	5.028E-08	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.521E-10	5.028E-08	CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.737E-09	6.833E-08	CYP2C9, CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.466E-08	8.179E-07	CYP2C9, CYP2A6, CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.255E-08	1.623E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.372E-09	2.470E-07	CA12, CA2, CA4, CA7
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.987E-05	2.986E-04	CYP2C9, CYP2D6, MAPK1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.816E-05	3.691E-04	MMP2, MAPK1, MMP9
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.820E-04	3.328E-03	CYP2C9, CYP2A6, GAA, CYP1A2, ALDH1A1, AKR1B1, CYP2C19, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.915E-04	4.200E-03	MMP2, MAPK1, MMP9
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.611E-04	7.816E-03	GAA, AKR1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.040E-04	4.956E-03	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.025E-05	2.986E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Cancer	C00-C96	MMP9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases