CMAUP Plant Collective Molecular Activities

Plant Name: Ancistrocladus korupensis

Taxonomic Information:

Plant ID: NPO2073
Plant Latin Name: Ancistrocladus korupensis
Taxonomy Genus: Ancistrocladus
Taxonomy Family: Ancistrocladaceae

Plant External Links:

NCBI TaxonomyDB: 63089
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA2B;
Enzyme_unclassified	ALPL; ALDH1A1; HSD17B10; GFER;
Hydrolase	GAA;
Lyase	CA7; CA4; CA6; CA12; CA9; CA1; CA14; CA5A;
Cysteine protease	CASP7; CASP1;
Transcription Factor	HIF1A; NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Small molecule receptor (family A GPCR)	ADORA2B	Adenosine A2b receptor	P29275	CHEMBL255
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.010E-21	2.199E-17	CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.741E-17	2.984E-13	CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.082E-15	1.118E-11	CA1, CA12, CA4, CA5A, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.370E-06	1.337E-02	CA1, CA12, CA4, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.885E-21	2.337E-19	CA12, CA1, CA5A, CA4, CA7, CA6, CA9, CA14
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.848E-05	7.486E-04	CASP7, CASP1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	4.701E-05	1.269E-03	CASP7, CASP1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.323E-03	2.317E-02	CASP1, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.716E-03	2.317E-02	CYP1A2, ALDH1A1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.664E-03	2.317E-02	CASP1, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.067E-03	3.731E-02	GAA, CYP1A2, ALDH1A1, ALPL, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.980E-03	3.448E-02	CASP1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	4.822E-03	3.731E-02	CASP7, NFKB1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.741E-03	3.731E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases