Plant Name: Ancistrocladus korupensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.010E-21 | 2.199E-17 | CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.741E-17 | 2.984E-13 | CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.082E-15 | 1.118E-11 | CA1, CA12, CA4, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.885E-21 | 2.337E-19 | CA12; CA1; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.848E-05 | 7.486E-04 | CASP7; CASP1; NFKB1 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 4.701E-05 | 1.269E-03 | CASP7; CASP1; NFKB1 |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.323E-03 | 2.317E-02 | CASP1; NFKB1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.716E-03 | 2.317E-02 | CYP1A2; ALDH1A1 |
| hsa04623 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.664E-03 | 2.317E-02 | CASP1; NFKB1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 5.067E-03 | 3.731E-02 | GAA; CYP1A2; ALDH1A1; ALPL; HSD17B10 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 4.242E-03 | 3.731E-02 | HIF1A; NFKB1 |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 2.980E-03 | 3.448E-02 | CASP1; NFKB1 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 4.822E-03 | 3.731E-02 | CASP7; NFKB1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.741E-03 | 3.731E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; CA1; NFKB1; HIF1A |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Apnea | R06.81 | ADORA2B |
| A00-B99: Certain infectious and parasitic diseases | Herpes simplex virus infection | B00 | ADORA2B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ADORA2B |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; HIF1A |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | ADORA2B |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| I00-I99: Diseases of the circulatory system | Paroxysmal supraventricular tachycardia | I47-I49, I47.1, I47.2, R00.0 | ADORA2B |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; HIF1A |
| I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | ADORA2B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |