Plant Name: Daphne aurantiaca
Taxonomic Information:
Plant ID: NPO2035
Plant Latin Name: Daphne aurantiaca
Taxonomy Genus: Daphne
Taxonomy Family: Thymelaeaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
831152-1
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; PTPN2; ACP1; CDC25B; PTPRF; | |
| RECQL; PLA2G1B; HPGD; HSD11B1; AKR1B10; HSD17B10; ALDH1A1; POLB; | |
| BCL2; | |
| LIMK1; LCK; | |
| RORC; | |
| NR1H4; | |
| CASP1; CASP7; | |
| MCL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | LIMK1 | LIM domain kinase 1 | P53667 | CHEMBL3836 |
| Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 7.849E-08 | 3.972E-04 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| BP | GO:0009987; cellular process | GO:2001244; positive regulation of intrinsic apoptotic signaling pathway | 4.457E-07 | 1.417E-03 | BCL2, LCK, MCL1, PTPN2 |
| BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 3.712E-06 | 5.389E-03 | BCL2, NR1H4 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
| BP | GO:0002376; immune system process | GO:0030217; T cell differentiation | 4.424E-06 | 5.723E-03 | BCL2, LCK, PTPN2, RORC |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 7.420E-06 | 8.503E-03 | PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 9.001E-06 | 9.533E-03 | ACP1, AKR1B10, ALDH1A1, CASP1, CASP7, CDC25B, HPGD, HSD11B1, HSD17B10, LCK, LIMK1, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL |
| MF | GO:0003824; catalytic activity | GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.193E-06 | 9.533E-03 | AKR1B10, HPGD, HSD11B1, HSD17B10 |
| MF | GO:0005488; binding | GO:0051434; BH3 domain binding | 1.236E-05 | 1.223E-02 | BCL2, MCL1 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.591E-05 | 1.946E-02 | AKR1B10, ALDH1A1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 7.119E-05 | 5.054E-03 | PTPN1, ACP1, PTPRF |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.690E-04 | 1.579E-02 | CASP7, BCL2, MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 6.671E-04 | 1.579E-02 | BCL2, PTPN2, MCL1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.425E-03 | 2.351E-02 | BCL2, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.656E-03 | 2.351E-02 | CASP7, CASP1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.050E-03 | 4.108E-02 | BCL2, CDC25B, MCL1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 3.053E-03 | 3.613E-02 | CASP7, CASP1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 4.651E-03 | 4.128E-02 | LCK, BCL2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 6.332E-03 | 4.995E-02 | PTPN1, PTPRF |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.834E-03 | 6.528E-02 | HSD11B1, AKR1B10, PLA2G1B, ALDH1A1, HSD17B10 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | MCL1; CDC25B; BCL2; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
