Plant Name: Daphne aurantiaca
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 7.849E-08 | 3.972E-04 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| BP | GO:0009987; cellular process | GO:2001244; positive regulation of intrinsic apoptotic signaling pathway | 4.457E-07 | 1.417E-03 | BCL2, LCK, MCL1, PTPN2 |
| BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 3.712E-06 | 5.389E-03 | BCL2, NR1H4 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
| BP | GO:0002376; immune system process | GO:0030217; T cell differentiation | 4.424E-06 | 5.723E-03 | BCL2, LCK, PTPN2, RORC |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 7.420E-06 | 8.503E-03 | PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 9.001E-06 | 9.533E-03 | ACP1, AKR1B10, ALDH1A1, CASP1, CASP7, CDC25B, HPGD, HSD11B1, HSD17B10, LCK, LIMK1, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL |
| MF | GO:0003824; catalytic activity | GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.193E-06 | 9.533E-03 | AKR1B10, HPGD, HSD11B1, HSD17B10 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 7.119E-05 | 5.054E-03 | PTPN1; ACP1; PTPRF |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 4.690E-04 | 1.579E-02 | CASP7; BCL2; MCL1 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 6.671E-04 | 1.579E-02 | BCL2; PTPN2; MCL1 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.425E-03 | 2.351E-02 | BCL2; CASP1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.656E-03 | 2.351E-02 | CASP7; CASP1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 4.050E-03 | 4.108E-02 | BCL2; CDC25B; MCL1 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 3.053E-03 | 3.613E-02 | CASP7; CASP1 |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 4.651E-03 | 4.128E-02 | LCK; BCL2 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 6.332E-03 | 4.995E-02 | PTPN1; PTPRF |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | BCL2; BCL2; MCL1; CDC25B |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2 |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1; PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |