CMAUP Plant Collective Molecular Activities

Plant Name: Melicope semecarpifolia

Taxonomic Information:

Plant ID: NPO20244
Plant Latin Name: Melicope semecarpifolia
Taxonomy Genus: Melicope
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 697038
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Philippines; China

Traditional Medicine System:

TCM

Geographical Distribution:

Philippines; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA2; CA3; CA14; CA7; CA5A; CA6; CA12; CA9; CA1;
ATP-binding cassette	ABCG2;
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	XPO1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Unclassified	XPO1	Exportin-1	O14980	CHEMBL5661
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.070E-08	1.519E-04	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.550E-26	1.209E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	2.625E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.787E-21	8.478E-17	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.031E-19	4.372E-15	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.631E-06	1.049E-02	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	9.631E-06	1.049E-02	CA1, CA2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.384E-05	1.435E-02	CA2, CA9, SLCO1B3, TSHR
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.884E-05	2.730E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.970E-25	6.303E-24	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.323E-05	3.716E-04	CA2, SLCO1B3, ABCG2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	2.566E-03	CYP1A2, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.364E-03	1.091E-02	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.920E-03	1.229E-02	CYP1A2, CYP2C19
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.139E-02	8.556E-02	CA2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.825E-02	8.342E-02	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	5.533E-02	9.702E-02	TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.685E-02	9.702E-02	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.994E-03	2.130E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases