Plant Name: Styrax
Taxonomic Information:
Plant ID: NPO20060
Plant Latin Name: Styrax
Taxonomy Genus: Styrax
Taxonomy Family: Styracaceae
Plant External Links:
NCBI TaxonomyDB:
13699
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| FFAR4; GPBAR1; FFAR1; HCAR2; | |
| PTPN1; PTPN2; CDC25B; | |
| TDP1; PLA2G1B; ALOX15; HPGD; ALDH1A1; AKR1B10; POLB; | |
| PPARA; PPARD; PPARG; | |
| NR1H4; | |
| FABP3; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | HCAR2 | Hydroxycarboxylic acid receptor 2 | Q8TDS4 | CHEMBL3785 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.970E-09 | 2.144E-05 | FFAR4, NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.119E-07 | 2.714E-04 | NR1H4, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 4.519E-07 | 4.100E-04 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.547E-06 | 1.162E-03 | FABP3, FFAR1, NR1H4, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.715E-06 | 1.245E-03 | FFAR1, FFAR4, GPBAR1, HCAR2, HPGD, NR1H4, PPARA, PPARD, PPARG, TSHR |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.375E-06 | 1.986E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 3.375E-06 | 1.986E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 6.746E-06 | 2.720E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0045834; positive regulation of lipid metabolic process | 8.616E-06 | 3.345E-03 | FABP3, NR1H4, PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.073E-05 | 3.768E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.124E-05 | 3.823E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0042981; regulation of apoptotic process | 1.311E-05 | 3.909E-03 | FFAR4, HCAR2, HPGD, LMNA, NR1H4, PPARD, PPARG, PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.397E-05 | 4.112E-03 | FABP3, PLA2G1B, PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 1.684E-05 | 4.425E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 1.684E-05 | 4.425E-03 | PPARG, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 1.684E-05 | 4.425E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.684E-05 | 4.425E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 1.684E-05 | 4.425E-03 | FABP3, PPARG |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.976E-05 | 4.889E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 2.372E-05 | 5.614E-03 | FFAR1, NR1H4, PPARG, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.356E-05 | 5.614E-03 | AKR1B10, ALDH1A1 |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.431E-05 | 5.692E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015909; long-chain fatty acid transport | 2.505E-05 | 5.742E-03 | FABP3, PLA2G1B, PPARG |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 3.454E-05 | 7.163E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0071073; positive regulation of phospholipid biosynthetic process | 4.034E-05 | 7.986E-03 | FABP3, NR1H4 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 4.034E-05 | 7.986E-03 | NR1H4, PLA2G1B |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 5.039E-05 | 9.690E-03 | PTPN1, PTPN2 |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 5.039E-05 | 9.690E-03 | HPGD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 7.427E-07 | 3.862E-05 | FABP3, PPARG, PPARA, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.191E-04 | 1.090E-02 | PLA2G1B, ALOX15 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.131E-03 | 1.960E-02 | HCAR2, PPARA, TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.912E-03 | 2.485E-02 | PLA2G1B, ALOX15 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 5.776E-03 | 6.007E-02 | PTPN1, PPARA |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.512E-02 | 1.310E-01 | HPGD, PPARG |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 3.767E-02 | 1.499E-01 | AKR1B10, PLA2G1B, ALOX15, ALDH1A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 3.003E-02 | 1.499E-01 | PPARG |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 2.594E-02 | 1.499E-01 | PLA2G1B |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 5.721E-02 | 1.499E-01 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
