Plant Name: Styrax
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.970E-09 | 2.144E-05 | FFAR4, NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.119E-07 | 2.714E-04 | NR1H4, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 4.519E-07 | 4.100E-04 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.547E-06 | 1.162E-03 | FABP3, FFAR1, NR1H4, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.715E-06 | 1.245E-03 | FFAR1, FFAR4, GPBAR1, HCAR2, HPGD, NR1H4, PPARA, PPARD, PPARG, TSHR |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.375E-06 | 1.986E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 3.375E-06 | 1.986E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 6.746E-06 | 2.720E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0045834; positive regulation of lipid metabolic process | 8.616E-06 | 3.345E-03 | FABP3, NR1H4, PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.073E-05 | 3.768E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.124E-05 | 3.823E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0045937; positive regulation of phosphate metabolic process | 1.165E-05 | 3.842E-03 | ALOX15, CDC25B, FABP3, FFAR4, NR1H4, PLA2G1B, PTPN1, TSHR |
| BP | GO:0009987; cellular process | GO:0042981; regulation of apoptotic process | 1.311E-05 | 3.909E-03 | FFAR4, HCAR2, HPGD, LMNA, NR1H4, PPARD, PPARG, PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.397E-05 | 4.112E-03 | FABP3, PLA2G1B, PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 1.684E-05 | 4.425E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 1.684E-05 | 4.425E-03 | PPARG, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 1.684E-05 | 4.425E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.684E-05 | 4.425E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 1.684E-05 | 4.425E-03 | FABP3, PPARG |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.976E-05 | 4.889E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 2.372E-05 | 5.614E-03 | FFAR1, NR1H4, PPARG, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.356E-05 | 5.614E-03 | AKR1B10, ALDH1A1 |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.431E-05 | 5.692E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015909; long-chain fatty acid transport | 2.505E-05 | 5.742E-03 | FABP3, PLA2G1B, PPARG |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 3.454E-05 | 7.163E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0071073; positive regulation of phospholipid biosynthetic process | 4.034E-05 | 7.986E-03 | FABP3, NR1H4 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 4.034E-05 | 7.986E-03 | NR1H4, PLA2G1B |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 5.039E-05 | 9.690E-03 | PTPN1, PTPN2 |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 5.039E-05 | 9.690E-03 | HPGD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 7.427E-07 | 3.862E-05 | FABP3; PPARG; PPARA; PPARD |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 4.191E-04 | 1.090E-02 | PLA2G1B; ALOX15 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.131E-03 | 1.960E-02 | HCAR2; PPARA; TSHR |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.912E-03 | 2.485E-02 | PLA2G1B; ALOX15 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PLA2G1B |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PPARG |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; PPARD; GPBAR1; PPARG; PPARG; FFAR1; HCAR2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | HCAR2; PLA2G1B |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD; HCAR2 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; PPARG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | HCAR2 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | PPARG |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; PPARD; PPARD; PPARG |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PPARG; PPARG |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | HCAR2 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; PPARG; FFAR1 |
| I00-I99: Diseases of the circulatory system | Acute ischemic stroke | I61-I63 | HCAR2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD; HCAR2 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |