Plant Name: Jasminum sambac
Taxonomic Information:
Plant ID: NPO19860
Plant Latin Name: Jasminum sambac
Taxonomy Genus: Jasminum
Taxonomy Family: Oleaceae
Plant External Links:
NCBI TaxonomyDB:
660624
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Philippines; Indonesia; India; Malaysia; Vietnam; China; ThailandTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCMGeographical Distribution:
Philippines; Indonesia; India; Malaysia; Vietnam; China; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CA2; CA12; CA1; CA9; | |
| PTGS1; | |
| HSD17B1; | |
| MCL1; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 7.744E-11 | 1.686E-06 | CA1, CA12, CA2, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.321E-09 | 3.616E-05 | CA1, CA12, CA2, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.636E-09 | 5.543E-05 | CA1, CA12, CA2, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 4.417E-06 | 1.202E-02 | CA1, CA2 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 8.025E-06 | 1.942E-02 | CYP19A1, CYP1A2, HSD17B1, NPC1 |
| MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 1.040E-05 | 2.265E-02 | CA1, CA12, CA2, CA9, CYP19A1, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 2.292E-05 | 4.537E-02 | CYP19A1, HSD17B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.174E-10 | 3.053E-09 | CA12, CA1, CA2, CA9 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 3.756E-06 | 4.883E-05 | HSD17B1, CYP1A2, CYP19A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 3.321E-04 | 2.878E-03 | HSD17B1, CYP19A1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 3.402E-03 | 1.769E-02 | HSD17B1, CYP1A2, CYP19A1, PTGS1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 2.179E-02 | 6.294E-02 | CYP1A2 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 1.475E-02 | 5.148E-02 | CA2 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.258E-02 | 5.148E-02 | CA2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.584E-02 | 5.148E-02 | CYP1A2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.837E-02 | 6.494E-02 | CA2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 2.747E-03 | 1.769E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1; |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1; |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1; |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
