CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	AURKB; AURKA; KDR; CSNK2A1;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	GFER; HSD17B1;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722

Showing 1 to 10 of 13 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.850E-08	1.551E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.145E-07	7.436E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.185E-07	7.436E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.507E-06	3.033E-03	CYP1A1, CYP1A2
BP	GO:0023052; signaling	GO:0023051; regulation of signaling	5.113E-06	4.124E-03	ACHE, AURKA, AURKB, CSNK2A1, CYP19A1, CYP1B1, ESR2, GFER, KDR, THPO
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	6.843E-06	4.807E-03	AURKA, AURKB, CSNK2A1, KDR
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.168E-05	7.481E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.286E-05	8.001E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, GFER, HSD17B1
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	4.177E-06	3.954E-03	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.084E-09	1.991E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.174E-10	7.391E-09	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.090E-06	2.369E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.300E-05	1.105E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.927E-04	4.492E-03	CYP1A2, CYP1A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.430E-08	4.131E-07	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.844E-05	1.254E-04	CYP1A2, CYP1A1, CYP1B1

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;

Showing 1 to 10 of 64 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Eupatorium leucolepis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities