Plant Name: Eupatorium leucolepis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TAS2R31; | |
| TSHR; | |
| ADORA3; | |
| ACHE; | |
| TDP1; PKM; HSD17B1; GFER; NOX4; ALOX15; USP2; TNKS; TNKS2; | |
| CFTR; | |
| GSK3B; SYK; CDK6; FLT3; PIM1; KDR; AURKB; AURKA; CSNK2A1; | |
| AR; | |
| ESR2; ESR1; | |
| MAOA; PTGS2; XDH; | |
| TP53; HIF1A; | |
| ABCG2; ABCC1; | |
| RAB9A; NPC1; MAPT; THPO; TTR; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Chloride channel | CFTR | Cystic fibrosis transmembrane conductance regulator | P13569 | CHEMBL4051 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | SYK | Tyrosine-protein kinase SYK | P43405 | CHEMBL2599 |
| Protein Kinase | CDK6 | Cyclin-dependent kinase 6 | Q00534 | CHEMBL2508 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Taste receptor (taste family GPCR) | TAS2R31 | Taste receptor type 2 member 31 | P59538 | CHEMBL2034804 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Unclassified | TTR | Transthyretin | P02766 | CHEMBL3194 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 6.461E-10 | 2.144E-06 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.404E-09 | 2.907E-06 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 1.042E-08 | 7.825E-06 | AURKA, AURKB, CSNK2A1, FLT3, GSK3B, KDR, PIM1, SYK |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.257E-08 | 8.553E-06 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4, PTGS2 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 3.163E-08 | 1.601E-05 | AURKB, CFTR, HIF1A, NPC1, PTGS2, SYK, TNKS, TNKS2 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 3.486E-08 | 1.725E-05 | AR, CYP3A4, ESR1, ESR2, HSD17B1, NPC1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.883E-08 | 2.562E-05 | ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 6.816E-08 | 2.748E-05 | AURKB, CDK6, CFTR, HIF1A, KDR, NPC1, PTGS2, SYK, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0016579; protein deubiquitination | 1.837E-07 | 6.348E-05 | AR, CFTR, ESR1, HIF1A, TNKS, TNKS2, TP53, USP2 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 3.353E-07 | 1.000E-04 | AR, CDK6, CSNK2A1, ESR1, FLT3, HIF1A, KDR, PIM1, PTGS2, SYK, THPO, TSHR |
| BP | GO:0050896; response to stimulus | GO:1901701; cellular response to oxygen-containing compound | 5.540E-07 | 1.547E-04 | AR, CDK6, CFTR, CYP1B1, ESR1, GSK3B, NOX4, PKM, PTGS2, TP53, TSHR |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 7.315E-07 | 1.918E-04 | CSNK2A1, HIF1A, KDR, MAPT |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 1.148E-06 | 2.736E-04 | ABCG2, ACHE, CSNK2A1, ESR1, ESR2, FLT3, KDR, MAPT, PKM, PTGS2, RAB9A, TP53, TTR, USP2, XDH |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.220E-06 | 2.856E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 1.643E-06 | 3.688E-04 | MAPT, NOX4, PTGS2, TP53, XDH |
| BP | GO:0032501; multicellular organismal process | GO:0060736; prostate gland growth | 1.675E-06 | 3.721E-04 | AR, CYP19A1, ESR1 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 2.080E-06 | 4.441E-04 | ABCC1, ABCG2, AURKA, AURKB, CDK6, CFTR, CSNK2A1, FLT3, GSK3B, KDR, PIM1, PKM, SYK, TP53 |
| BP | GO:0050896; response to stimulus | GO:0009611; response to wounding | 2.671E-06 | 5.435E-04 | ACHE, ADORA3, ALOX15, AURKA, CYP1A1, TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 4.841E-06 | 8.711E-04 | ESR1, ESR2 |
| BP | GO:0065007; biological regulation | GO:1904355; positive regulation of telomere capping | 6.837E-06 | 1.128E-03 | AURKB, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.329E-05 | 1.969E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 1.416E-05 | 2.084E-03 | AR, AURKA, AURKB, CSNK2A1, GSK3B, HIF1A, KDR, PIM1, PTGS2, TP53 |
| BP | GO:0009987; cellular process | GO:0043410; positive regulation of MAPK cascade | 1.458E-05 | 2.088E-03 | ALOX15, AR, FLT3, KDR, NOX4, SYK, THPO, XDH |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 1.450E-05 | 2.088E-03 | ALOX15, PTGS2 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 1.450E-05 | 2.088E-03 | CYP1A1, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.764E-05 | 2.447E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 2.206E-05 | 2.911E-03 | CYP1A1, HIF1A, NOX4, PKM, PTGS2, TP53 |
| BP | GO:0050896; response to stimulus | GO:0071417; cellular response to organonitrogen compound | 2.421E-05 | 3.169E-03 | CFTR, GSK3B, NOX4, PKM, PTGS2, TP53, TSHR |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 2.431E-05 | 3.169E-03 | AURKA, CSNK2A1, FLT3, PKM |
| BP | GO:0008152; metabolic process | GO:0006706; steroid catabolic process | 2.578E-05 | 3.322E-03 | CYP19A1, CYP1A2, CYP3A4 |
| BP | GO:0032501; multicellular organismal process | GO:0010575; positive regulation of vascular endothelial growth factor production | 2.896E-05 | 3.583E-03 | CYP1B1, HIF1A, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 2.896E-05 | 3.583E-03 | TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 2.896E-05 | 3.583E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 2.896E-05 | 3.583E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.896E-05 | 3.583E-03 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008209; androgen metabolic process | 3.238E-05 | 3.917E-03 | CYP19A1, CYP3A4, ESR1 |
| MF | GO:0005488; binding | GO:0008013; beta-catenin binding | 3.282E-05 | 3.926E-03 | AR, CSNK2A1, ESR1, GSK3B |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 3.555E-05 | 4.207E-03 | CDK6, CFTR, CYP1B1, KDR, PTGS2, TP53 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 4.422E-05 | 5.042E-03 | ABCC1, ALOX15, SYK |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 4.820E-05 | 5.410E-03 | CYP1A1, CYP3A4 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 4.820E-05 | 5.410E-03 | AURKA, AURKB |
| BP | GO:0065007; biological regulation | GO:0032212; positive regulation of telomere maintenance via telomerase | 5.860E-05 | 6.194E-03 | AURKB, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 7.220E-05 | 7.278E-03 | CYP1A1, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 7.220E-05 | 7.278E-03 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0046983; protein dimerization activity | 7.199E-05 | 7.278E-03 | ABCG2, ACHE, AR, AURKA, FLT3, HIF1A, MAPT, PTGS2, TP53, TTR, XDH |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 7.220E-05 | 7.278E-03 | AURKA, AURKB |
| BP | GO:0008152; metabolic process | GO:0046456; icosanoid biosynthetic process | 7.574E-05 | 7.565E-03 | ALOX15, PTGS2, SYK |
| BP | GO:0009987; cellular process | GO:0080135; regulation of cellular response to stress | 8.053E-05 | 7.935E-03 | CDK6, GSK3B, HIF1A, MAPT, PTGS2, SYK, TP53, XDH |
| BP | GO:0040007; growth | GO:0040008; regulation of growth | 8.406E-05 | 8.228E-03 | AR, CSNK2A1, ESR2, HIF1A, MAPT, PIM1, TNKS2, TP53 |
| BP | GO:0051179; localization | GO:0051222; positive regulation of protein transport | 8.426E-05 | 8.228E-03 | ACHE, CFTR, GSK3B, HIF1A, PTGS2, SYK, TP53 |
| BP | GO:0032501; multicellular organismal process | GO:0001889; liver development | 8.643E-05 | 8.364E-03 | AURKA, CSNK2A1, GFER, PKM |
| BP | GO:0009987; cellular process | GO:0007346; regulation of mitotic cell cycle | 8.958E-05 | 8.585E-03 | AURKA, AURKB, CDK6, CYP1A1, PIM1, TNKS, TP53, USP2 |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 9.642E-05 | 9.089E-03 | CYP19A1, CYP1A2, NOX4, XDH |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 1.009E-04 | 9.295E-03 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0005102; receptor binding | 9.958E-05 | 9.295E-03 | AR, ESR1, ESR2, FLT3, GFER, HIF1A, KDR, MAPT, SYK, THPO, TP53, TTR |
| MF | GO:0060089; molecular transducer activity | GO:0005021; vascular endothelial growth factor-activated receptor activity | 1.009E-04 | 9.295E-03 | FLT3, KDR |
| MF | GO:0005488; binding | GO:0070324; thyroid hormone binding | 1.009E-04 | 9.295E-03 | PKM, TTR |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 1.009E-04 | 9.295E-03 | ABCC1, ABCG2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.558E-09 | 3.325E-07 | HSD17B1; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 7.125E-08 | 4.631E-06 | HSD17B1; CYP1A1; CYP1B1; PTGS2; CYP19A1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.600E-06 | 5.199E-05 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 8.722E-07 | 3.780E-05 | CYP1A2; CYP1A1; CYP1B1; CYP3A4; PTGS2 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 2.004E-05 | 3.256E-04 | AR; GSK3B; CDK6; FLT3; PTGS2; HIF1A; TP53 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 1.056E-05 | 2.746E-04 | GSK3B; CDK6; CSNK2A1; RAB9A; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.286E-05 | 2.787E-04 | PKM; FLT3; TP53; HIF1A |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.810E-05 | 3.256E-04 | CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 3.916E-05 | 5.090E-04 | ABCC1; CDK6; PIM1; CYP1B1; PTGS2; TP53 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.348E-04 | 2.180E-03 | PKM; MAOA; HSD17B1; CYP1A2; ALOX15; CYP1A1; PTGS2; CYP3A4; CYP19A1; XDH |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.190E-04 | 1.190E-03 | GSK3B; TP53; ESR1; HIF1A |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.253E-05 | 4.699E-04 | CYP1A2; ALOX15; CYP3A4 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 7.914E-04 | 5.240E-03 | GSK3B; CDK6; SYK; KDR; TP53 |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 1.153E-04 | 1.190E-03 | ABCC1; CFTR; ABCG2 |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 4.979E-04 | 3.596E-03 | GSK3B; ESR1; ESR2 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 3.685E-04 | 3.193E-03 | CYP1A2; CYP1A1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 4.393E-04 | 3.570E-03 | MAOA; CYP1A2; CYP3A4 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 9.159E-04 | 5.240E-03 | GSK3B; SYK; CSNK2A1; TP53 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 9.329E-04 | 5.240E-03 | KDR; TP53; HIF1A; ESR1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 9.675E-04 | 5.240E-03 | CDK6; PKM; SYK; TP53 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 9.243E-04 | 5.240E-03 | GSK3B; AR; TP53 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.778E-04 | 3.596E-03 | CYP3A4; CFTR; ABCG2 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 8.366E-04 | 5.240E-03 | CDK6; PTGS2; TP53 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.792E-03 | 8.962E-03 | MAOA; ALOX15; PTGS2 |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.050E-03 | 5.459E-03 | SYK; CSNK2A1; PTGS2 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.182E-03 | 1.051E-02 | ABCC1; ADORA3; TP53 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 3.513E-03 | 1.575E-02 | GSK3B; CSNK2A1; TP53 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 2.396E-03 | 1.112E-02 | GSK3B; CDK6; TP53 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 6.460E-03 | 2.470E-02 | CDK6; TP53 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 5.593E-03 | 2.345E-02 | GSK3B; TP53 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 6.460E-03 | 2.470E-02 | PTGS2; TSHR |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 7.625E-03 | 2.692E-02 | KDR; PTGS2 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 6.686E-03 | 2.483E-02 | FLT3; PIM1 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 8.619E-03 | 2.873E-02 | CDK6; TP53 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 6.238E-03 | 2.470E-02 | GSK3B; TP53 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 7.868E-03 | 2.692E-02 | GSK3B; TP53 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 8.877E-03 | 2.885E-02 | CDK6; TP53 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.021E-02 | 3.162E-02 | CDK6; TP53 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.077E-02 | 3.183E-02 | CDK6; TP53 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.077E-02 | 3.183E-02 | GSK3B; SYK |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 4.401E-03 | 1.907E-02 | CYP3A4; XDH |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 7.868E-03 | 2.692E-02 | ALOX15; PTGS2 |
| hsa04640 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.538E-02 | 4.442E-02 | THPO; FLT3 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 9.669E-03 | 3.066E-02 | CDK6; TP53 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.497E-05 | 5.314E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; KDR; FLT3 |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3 |
| K00-K95: Diseases of the digestive system | Colon polyps | K63.5 | PTGS2 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| N00-N99: Diseases of the genitourinary system | Post-menopausal vaginal atrophy | N95.2 | ESR1 |
| NA: NA | Postmenopausal disorder | NA | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | TTR |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; SYK; TP53; KDR; KDR; KDR; FLT3; PKM; AURKB; AURKA |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Diarrhea | A09, K59.1 | CFTR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Moderate to severe rheumatoid arthritis | M05-M06 | PTGS2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| NA: NA | Rheumatold arthritis | NA | PTGS2; PTGS2; PTGS2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | SYK; PTGS2; PTGS2; PTGS2; PTGS2 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | ESR1; ESR1 |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR; ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; ESR1; ESR1 |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| A00-B99: Certain infectious and parasitic diseases | HIV-associated diarrhoea | A09 | CFTR |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | SYK |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | GSK3B; ACHE; ACHE; ACHE; MAOA; PTGS2; MAPT |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; KDR |
| I00-I99: Diseases of the circulatory system | Cardiomyopathy | I42.0 | TTR |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR |
| C00-D49: Neoplasms | Refractory renal cell carcinoma | C64 | PKM |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3; KDR |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; GSK3B; HIF1A; SYK; ADORA3; TP53; KDR; FLT3; FLT3; ACHE; ESR1; ESR1; PIM1; PTGS2; AURKA; CSNK2A1 |
| C00-D49: Neoplasms | Carcinoma | D00-D09 | ESR1 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cancer | C64 | KDR |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Knee osteoarthritis | M15-M19, M47 | PTGS2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PTGS2; PTGS2; ABCC1 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | SYK; SYK; PTGS2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Hyperthermia | T68 | PTGS2 |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; CYP19A1; KDR; KDR; KDR; FLT3; FLT3; ESR1; ESR1 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | ESR1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; CYP19A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; AR; FLT3; ESR1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | FLT3 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | GSK3B |
| Z00-Z99: Factors influencing health status and contact with health services | Hormone replacement therapy | Z79.890 | ESR1 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53; FLT3; FLT3; AURKB; AURKA |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthralgia | M25.5 | ESR1 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| C00-D49: Neoplasms | B-cell lymphoma | C85.1 | SYK |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ADORA3; ACHE |
| NA: NA | GIST | NA | FLT3 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH; PTGS2; ABCC1; ABCC1 |
| NA: NA | Gonorrheal vaginitis | NA | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; MAOA |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; FLT3; PTGS2 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; ACHE; ESR1; PTGS2; PTGS2; PTGS2; PTGS2; PKM |
| N00-N99: Diseases of the genitourinary system | Atrophic vaginitis | N95.2 | ESR1 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; AR; ESR1 |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| C00-D49: Neoplasms | AML | NA | KDR; FLT3 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; XDH |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; KDR; KDR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2 |
| Z00-Z99: Factors influencing health status and contact with health services | Oral contraceptive | Z30 | ESR1 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Osteopetrosis | Q78.2 | ESR1 |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | GSK3B |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | SYK; ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Atrophy | M62.571 | ESR1 |
| NA: NA | Male hypogonadism | NA | AR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Estrogen deficiency | E28.39 | ESR1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| NA: NA | Menopausal disorder | NA | ESR1 |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; KDR |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; MAPT |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| N00-N99: Diseases of the genitourinary system | Dyspareunia | N94.1 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | ESR1; PTGS2; PTGS2; PTGS2; PTGS2 |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | SYK |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | KDR; PTGS2 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SYK; TP53; AURKB |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| NA: NA | Hepatitis C virus infection | NA | ADORA3 |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| N00-N99: Diseases of the genitourinary system | Menorrhagia | N92.0 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Menopause symptoms | N95.0 | ESR1; ESR1 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; PTGS2 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3; PTGS2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | SYK; PTGS2 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| N00-N99: Diseases of the genitourinary system | Infertility | N97.0 | ESR1 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTGS2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | TTR amyloidosis | E85 | TTR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR; ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| NA: NA | Joint and muscular pain | NA | PTGS2 |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3 |
| N00-N99: Diseases of the genitourinary system | Irregularities | N92.6 | ESR1 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; KDR; KDR; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Female hypogonadism | E23, E28 | ESR1 |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| C00-D49: Neoplasms | Liver cancer | C22 | KDR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; AURKA |
| C00-D49: Neoplasms | Leukemia | C90-C95 | FLT3; ESR1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; CYP3A4; MAOA |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | SYK |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | PTGS2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; MAPT |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Female infertility | N97.0 | ESR1; ESR1 |
| N00-N99: Diseases of the genitourinary system | Female infertility due to anovulation | N97.0 | ESR1 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR; CFTR |
| H00-H59: Diseases of the eye and adnexa | Eye disorders | H00-H59 | ESR1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | SYK |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR; ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA; PTGS2; PTGS2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | ESR1 |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR; ESR1 |
| N00-N99: Diseases of the genitourinary system | Vagina disease | N76.0 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Ankylosing spondylitis | M08.1, M45 | PTGS2 |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |