CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HRH3; HRH4; HRH2; HRH1;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	BLM; GLA;
GABA-A receptor	GABRR2;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
GABA-A receptor	GABRR2	GABA receptor rho-2 subunit	P28476	CHEMBL2375
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Small molecule receptor (family A GPCR)	HRH3	Histamine H3 receptor	Q9Y5N1	CHEMBL264
Small molecule receptor (family A GPCR)	HRH4	Histamine H4 receptor	Q9H3N8	CHEMBL3759

Showing 1 to 10 of 14 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0045761; regulation of adenylate cyclase activity	4.224E-06	1.840E-02	HRH3, HRH4, TSHR
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	2.434E-02	CYP2C19, CYP3A4
BP	GO:0009987; cellular process	GO:0007186; G-protein coupled receptor signaling pathway	1.332E-05	2.637E-02	GABRR2, HRH1, HRH2, HRH3, HRH4, NPSR1, TSHR
BP	GO:0008152; metabolic process	GO:0032769; negative regulation of monooxygenase activity	2.673E-05	4.158E-02	GLA, NFKB1
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.206E-05	4.654E-02	CYP2C19, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0004969; histamine receptor activity	2.587E-12	5.634E-08	HRH1, HRH2, HRH3, HRH4

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	7.676E-03	CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	2.910E-02	CYP3A4, CYP2C19
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo series	9.759E-03	1.025E-01	GLA
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.830E-08	1.537E-06	GABRR2, HRH1, HRH3, HRH2, HRH4, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	6.827E-03	9.558E-02	HRH1, HRH2
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	8.286E-03	9.943E-02	NFKB1, TSHR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.190E-03	7.039E-02	LMNA, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	6.385E-02	1.038E-01	NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.464E-03	3.073E-02	CYP3A4, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	7.041E-02	1.038E-01	NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; HRH1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	HRH4;
C00-D49: Neoplasms	Allergic conjunctivitis	C91.0, H10, H10.45, T78.4	HRH1;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HRH1; HRH3;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3;

Showing 1 to 10 of 58 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Grindelia havardii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities