CMAUP Plant Collective Molecular Activities

Plant Name: Grindelia havardii

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004969; histamine receptor activity	2.587E-12	5.634E-08	HRH1, HRH2, HRH3, HRH4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.830E-08	1.537E-06	GABRR2; HRH1; HRH3; HRH2; HRH4; TSHR
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.828E-04	7.676E-03	CYP3A4; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.039E-03	2.910E-02	CYP3A4; CYP2C19
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.464E-03	3.073E-02	CYP3A4; CYP2C19

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	HRH2
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HRH2
J00-J99: Diseases of the respiratory system	Hay fever	J30	HRH1; HRH1; HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	HRH1; HRH1
K00-K95: Diseases of the digestive system	Gastric secretory disorders	K30	HRH2
NA: NA	Vertigo's disease	NA	HRH1
NA: NA	Vomiting	NA	HRH1
H60-H95: Diseases of the ear and mastoid process	Vertigo meniere's disease	H81, H81.0, R42	HRH1
NA: NA	Coughs	NA	HRH1
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HRH3
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	HRH2
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
K00-K95: Diseases of the digestive system	Acid-reflux disorders	K21	HRH2
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; HRH1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Dry cough	R05	HRH1
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	HRH1; HRH1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	HRH4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HRH1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HRH3; HRH3; HRH1; HRH2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HRH3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	HRH1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	HRH4
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	HRH1; HRH1
NA: NA	Morning sickness	NA	HRH1
J00-J99: Diseases of the respiratory system	Asthma	J45	HRH4; HRH1
NA: NA	Urticaria	NA	HRH1; HRH1; HRH1
J00-J99: Diseases of the respiratory system	Seasonal and perennial allergic rhinitis and vasomotor rhinitis	J30	HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HRH3; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	HRH3
NA: NA	Allergic disorders	NA	HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HRH3; HRH1
H00-H59: Diseases of the eye and adnexa	Ocular allergy	H00-H59	HRH1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	HRH2
NA: NA	Perennial and seasonal allergic rhinitis	NA	HRH1
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	HRH2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HRH3
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Allergic conjunctivitis	C91.0, H10, H10.45, T78.4	HRH1; HRH1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	HRH3; HRH4; HRH1; HRH1; HRH1; HRH1; HRH1
L00-L99: Diseases of the skin and subcutaneous tissue	Allergic skin disorders	L00-L99	HRH1
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	HRH1; HRH1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HRH3; HRH3
NA: NA	Meniere's disease	NA	HRH1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	HRH1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	HRH1
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	HRH1; HRH1
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	HRH1
E00-E89: Endocrine, nutritional and metabolic diseases	Fabry's disease	E75.2	GLA
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
NA: NA	Hypersensitivity reactions	NA	HRH1
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3
NA: NA	Common cold	NA	HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HRH3; HRH1; HRH1; HRH1; CYP3A4
NA: NA	Respiratory allergies	NA	HRH1; HRH1
K00-K95: Diseases of the digestive system	Gastric ulcer	K25	HRH2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HRH3; HRH1
NA: NA	Vasomotor rhinitis	NA	HRH1
NA: NA	Itching	NA	HRH1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HRH3; NPSR1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HRH1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases