CMAUP Plant Collective Molecular Activities

Plant Name: Macleaya cordata

Taxonomic Information:

Plant ID: NPO19264
Plant Latin Name: Macleaya cordata
Taxonomy Genus: Macleaya
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 56857
Plant-of-the-World-Online: 673258-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Carminative; Depurative; Diuretic; Stings

Geographical Distribution:

Ukraine; United States; China; South Africa

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Enzyme_unclassified	MTOR; ALOX15;
Oxidoreductase	PTGS1;
Transcription Factor	TP53;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.660E-09	1.594E-05	CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.492E-07	1.613E-03	CYP1A2, CYP2C19, CYP2D6, PTGS1
MF	GO:0005488; binding	GO:0020037; heme binding	8.739E-07	2.114E-03	CYP1A2, CYP2C19, CYP2D6, PTGS1
MF	GO:0003824; catalytic activity	GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.878E-06	3.717E-03	CYP1A2, CYP2C19, CYP2D6, PTGS1
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.131E-06	3.867E-03	ALOX15, CYP1A2, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.561E-06	4.291E-03	CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	7.417E-06	1.009E-02	CYP1A2, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	1.306E-05	1.673E-02	ALOX15, MTOR, TP53
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.588E-05	1.921E-02	CYP1A2, CYP2C19
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	2.327E-05	2.303E-02	SMN1, SMN2
MF	GO:0003824; catalytic activity	GO:0004497; monooxygenase activity	2.455E-05	2.324E-02	CYP1A2, CYP2C19, CYP2D6
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.749E-05	2.494E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	5.383E-05	3.781E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.456E-07	2.062E-05	CYP2D6, ALOX15, CYP2C19, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.977E-07	2.062E-05	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.118E-06	1.407E-04	ALOX15, CYP2C19, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.456E-06	1.459E-04	CYP2D6, CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.722E-04	8.211E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.140E-04	8.211E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.255E-03	9.625E-03	TP53, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.470E-04	8.349E-03	CYP2D6, CYP1A2
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.399E-03	9.653E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	9.204E-03	CYP1A2, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases