Plant Name: Macleaya cordata
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.660E-09 | 1.594E-05 | CYP1A2, CYP2C19, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 5.492E-07 | 1.613E-03 | CYP1A2, CYP2C19, CYP2D6, PTGS1 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 8.739E-07 | 2.114E-03 | CYP1A2, CYP2C19, CYP2D6, PTGS1 |
| MF | GO:0003824; catalytic activity | GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 1.878E-06 | 3.717E-03 | CYP1A2, CYP2C19, CYP2D6, PTGS1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.131E-06 | 3.867E-03 | ALOX15, CYP1A2, CYP2C19, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 2.561E-06 | 4.291E-03 | CYP1A2, CYP2C19, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.456E-07 | 2.062E-05 | CYP2D6; ALOX15; CYP2C19; PTGS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.977E-07 | 2.062E-05 | CYP1A2; ALOX15; CYP2C19 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 6.118E-06 | 1.407E-04 | ALOX15; CYP2C19; PTGS1 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.456E-06 | 1.459E-04 | CYP2D6; CYP1A2; CYP2C19 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 6.722E-04 | 8.211E-03 | TP53; MTOR |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 7.140E-04 | 8.211E-03 | TP53; MTOR |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.255E-03 | 9.625E-03 | TP53; MTOR |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 8.470E-04 | 8.349E-03 | CYP2D6; CYP1A2 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.399E-03 | 9.653E-03 | TP53; MTOR |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.067E-03 | 9.204E-03 | CYP1A2; CYP2C19 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.192E-03 | 1.375E-02 | TP53; MTOR |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 1.628E-02 | LMNA; TP53 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 3.886E-03 | 1.915E-02 | THPO; MTOR |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 4.854E-03 | 2.093E-02 | CYP1A2; ALOX15; CYP2C19; PTGS1 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 4.586E-03 | 2.093E-02 | SMN2; SMN1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 6.328E-03 | 2.568E-02 | TP53; MTOR |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.997E-03 | 1.628E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1 |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; PTGS1 |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | PTGS1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; MTOR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |
| NA: NA | Rheumatold arthritis | NA | PTGS1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; MTOR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; PTGS1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| J00-J99: Diseases of the respiratory system | Throat irritation | J39.2 | TRPA1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; MTOR |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; PTGS1; TRPA1 |
| NA: NA | Miosis during ocular surgery | NA | PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1 |
| NA: NA | Coronary artery restenosis | NA | MTOR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS1 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1 |