CMAUP Plant Collective Molecular Activities

Plant Name: Begonia glabra

Taxonomic Information:

Plant ID: NPO19015
Plant Latin Name: Begonia glabra
Taxonomy Genus: Begonia
Taxonomy Family: Begoniaceae

Plant External Links:

NCBI TaxonomyDB: 62974
Plant-of-the-World-Online: 104759-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Brazil; Jamaica; Belize; Honduras; Peru; Suriname; Cuba; Venezuela; Mexico; Costa Rica; Trinidad and Tobago; Guatemala; China; Colombia; French Guiana; Bolivia; Nicaragua; Ecuador

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ATP1A1;
Enzyme_unclassified	RECQL;
Nuclear hormone receptor subfamily 1 group F	RORC;
Transcription Factor	STAT3; TP53;
SLC superfamily of solute carriers	SLCO4C1; SLCO1B1;
Unclassified	RAB9A; MAPT; PAX8; NPC1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
SLC superfamily of solute carriers	SLCO4C1	Solute carrier organic anion transporter family member 4C1	Q6ZQN7	CHEMBL2073690
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005496; steroid binding	2.540E-07	5.530E-03	ATP1A1, CYP3A4, NPC1, RORC

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.564E-05	2.744E-03	STAT3, RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	9.070E-05	3.492E-03	PAX8, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	4.745E-04	8.454E-03	STAT3, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	5.490E-04	8.454E-03	PAX8, ATP1A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.490E-04	8.454E-03	ATP1A1, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ATP1A1;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3; ATP1A1; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ATP1A1;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	ATP1A1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperhidrosis	R61	ATP1A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
NA: NA	Arrhythmias	NA	ATP1A1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3; TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3;
NA: NA	Congestive cardiac insufficiency	NA	ATP1A1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases