Plant Name: Begonia glabra
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005496; steroid binding | 2.540E-07 | 5.530E-03 | ATP1A1, CYP3A4, NPC1, RORC |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.195E-05 | 9.323E-04 | SLCO1B1; ATP1A1; CYP3A4 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 8.368E-05 | 3.264E-03 | STAT3; RAB9A; TP53 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 1.568E-04 | 4.076E-03 | PAX8; TP53 |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 7.927E-04 | 1.228E-02 | STAT3; RORC |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 8.172E-04 | 1.228E-02 | STAT3; TP53 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.914E-03 | 2.133E-02 | PAX8; STAT3; TP53 |
| hsa04918 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 9.450E-04 | 1.228E-02 | PAX8; ATP1A1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.580E-03 | 2.516E-02 | ATP1A1; TP53 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.608E-03 | 2.777E-02 | LMNA; TP53 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 3.263E-03 | 2.777E-02 | STAT3; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 3.916E-03 | 2.777E-02 | STAT3; TP53 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 7.429E-03 | 3.937E-02 | STAT3; TP53 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 7.358E-03 | 3.937E-02 | STAT3; TP53 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 7.571E-03 | 3.937E-02 | STAT3; TP53 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 5.886E-03 | 3.826E-02 | PAX8; TP53 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ATP1A1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | ATP1A1; STAT3; TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ATP1A1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | STAT3 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | ATP1A1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperhidrosis | R61 | ATP1A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | ATP1A1 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | STAT3 |
| NA: NA | Arrhythmias | NA | ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | ATP1A1; ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | STAT3; TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | STAT3 |
| NA: NA | Congestive cardiac insufficiency | NA | ATP1A1; ATP1A1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ATP1A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |