CMAUP Plant Collective Molecular Activities

Plant Name: Helenium amarum

Taxonomic Information:

Plant ID: NPO18919
Plant Latin Name: Helenium amarum
Taxonomy Genus: Helenium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 289417
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiphlogistic; Expectorant

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ADA;
Miscellaneous ion channel	BCL2;
Protein Kinase	MAPK1;
Enzyme_unclassified	TERT;
Transferase	MDM2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	XBP1; HTT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Hydrolase	ADA	Adenosine deaminase	P00813	CHEMBL1910
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transferase	MDM2	p53-binding protein Mdm-2	Q00987	CHEMBL5023
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0051050; positive regulation of transport	4.862E-07	2.117E-03	BCL2, HTT, MAPK1, MDM2, RAB9A, TERT, XBP1
BP	GO:0065007; biological regulation	GO:0031648; protein destabilization	2.074E-06	4.107E-03	HTT, MDM2, XBP1
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	4.985E-06	5.165E-03	MAPK1, NPC1, TERT
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	6.714E-06	5.165E-03	ADA, BCL2, MAPK1, MDM2, TERT, XBP1
BP	GO:0032502; developmental process	GO:0048732; gland development	1.099E-05	7.254E-03	ADA, BCL2, MAPK1, XBP1
BP	GO:0051179; localization	GO:0032880; regulation of protein localization	1.595E-05	9.529E-03	BCL2, MAPK1, MDM2, RAB9A, TERT, XBP1
MF	GO:0005488; binding	GO:0008134; transcription factor binding	1.733E-05	9.673E-03	BCL2, HTT, MAPK1, TERT, XBP1
CC	GO:0016020; membrane	GO:0016020; membrane	1.802E-05	9.812E-03	ADA, BCL2, CYP3A4, HTT, MAPK1, MDM2, NPC1, RAB9A, SLCO1B1, SLCO1B3, TERT, XBP1
CC	GO:0044464; cell part	GO:0005773; vacuole	4.223E-05	1.672E-02	ADA, HTT, NPC1, RAB9A
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	5.383E-05	1.954E-02	SLCO1B1, SLCO1B3
CC	GO:0044464; cell part	GO:0005770; late endosome	7.014E-05	2.213E-02	HTT, MAPK1, RAB9A
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	9.691E-05	2.814E-02	SLCO1B1, SLCO1B3
CC	GO:0044464; cell part	GO:0032839; dendrite cytoplasm	1.053E-04	2.951E-02	ADA, MAPK1
MF	GO:0005488; binding	GO:0042802; identical protein binding	2.116E-04	4.306E-02	BCL2, HTT, MAPK1, MDM2, RAB9A, TERT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.820E-05	1.029E-03	BCL2, MDM2, MAPK1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.218E-06	1.029E-03	SLCO1B1, SLCO1B3, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.671E-04	1.006E-02	MDM2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.722E-04	1.196E-02	MDM2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	6.117E-04	1.196E-02	BCL2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	6.457E-04	1.196E-02	MDM2, BCL2, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	9.641E-04	1.211E-02	MDM2, BCL2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	8.014E-04	1.196E-02	MDM2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.495E-03	1.506E-02	MDM2, BCL2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	8.470E-04	1.196E-02	MDM2, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immunodeficiency	D84.9	ADA;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	MDM2; ADA;
C00-D49: Neoplasms	Hairy cell leukemia	C91.4	ADA;
C00-D49: Neoplasms	Solid tumours	C00-D48	MDM2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ADA;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	MDM2;
C00-D49: Neoplasms	Prostate cancer	C61	MDM2;
C00-D49: Neoplasms	Cancer	C00-C96	MDM2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MDM2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases