Plant Name: Helenium amarum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0051050; positive regulation of transport | 4.862E-07 | 2.117E-03 | BCL2, HTT, MAPK1, MDM2, RAB9A, TERT, XBP1 |
| BP | GO:0065007; biological regulation | GO:0031648; protein destabilization | 2.074E-06 | 4.107E-03 | HTT, MDM2, XBP1 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 4.985E-06 | 5.165E-03 | MAPK1, NPC1, TERT |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 6.046E-06 | 5.165E-03 | ADA, BCL2, HTT, MAPK1, NPC1 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 6.714E-06 | 5.165E-03 | ADA, BCL2, MAPK1, MDM2, TERT, XBP1 |
| BP | GO:0051179; localization | GO:0051234; establishment of localization | 9.787E-06 | 6.660E-03 | ADA, HTT, MAPK1, MDM2, NPC1, RAB9A, SLCO1B1, SLCO1B3, TERT, XBP1 |
| BP | GO:0032502; developmental process | GO:0048732; gland development | 1.099E-05 | 7.254E-03 | ADA, BCL2, MAPK1, XBP1 |
| BP | GO:0051179; localization | GO:0032880; regulation of protein localization | 1.595E-05 | 9.529E-03 | BCL2, MAPK1, MDM2, RAB9A, TERT, XBP1 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 1.733E-05 | 9.673E-03 | BCL2, HTT, MAPK1, TERT, XBP1 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 1.802E-05 | 9.812E-03 | ADA, BCL2, CYP3A4, HTT, MAPK1, MDM2, NPC1, RAB9A, SLCO1B1, SLCO1B3, TERT, XBP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.820E-05 | 1.029E-03 | BCL2; MDM2; MAPK1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 9.218E-06 | 1.029E-03 | SLCO1B1; SLCO1B3; CYP3A4 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.671E-04 | 1.006E-02 | MDM2; MAPK1 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 6.722E-04 | 1.196E-02 | MDM2; MAPK1 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 6.117E-04 | 1.196E-02 | BCL2; MAPK1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 6.457E-04 | 1.196E-02 | MDM2; BCL2; MAPK1 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 9.641E-04 | 1.211E-02 | MDM2; BCL2; MAPK1 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 8.014E-04 | 1.196E-02 | MDM2; MAPK1 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.495E-03 | 1.506E-02 | MDM2; BCL2; MAPK1 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 8.470E-04 | 1.196E-02 | MDM2; MAPK1 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.612E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.943E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 1.676E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 2.192E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.192E-03 | 1.506E-02 | MDM2; MAPK1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 2.265E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 1.824E-02 | BCL2; MAPK1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.265E-03 | 1.506E-02 | BCL2; MAPK1 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 3.330E-03 | 1.840E-02 | BCL2; MAPK1 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 2.773E-03 | 1.741E-02 | MDM2; MAPK1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 3.419E-03 | 1.840E-02 | BCL2; MAPK1 |
| hsa04141 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 4.431E-03 | 2.276E-02 | XBP1; BCL2 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 6.328E-03 | 2.699E-02 | MDM2; MAPK1 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 6.268E-03 | 2.699E-02 | MDM2; BCL2 |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 6.268E-03 | 2.699E-02 | BCL2; MAPK1 |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 4.903E-03 | 2.409E-02 | BCL2; MAPK1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 6.449E-03 | 2.699E-02 | MDM2; MAPK1 |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 1.005E-02 | 4.054E-02 | XBP1; TERT |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2 |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Immunodeficiency | D84.9 | ADA |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2 |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | ADA; MDM2 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT |
| C00-D49: Neoplasms | Hairy cell leukemia | C91.4 | ADA |
| C00-D49: Neoplasms | Melanoma | C43 | TERT |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2 |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; TERT |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MDM2; MAPK1 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | ADA |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | MDM2; TERT |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; TERT |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; MDM2; TERT |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | BCL2; BCL2; MDM2; MDM2; MAPK1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MDM2 |