Plant Name: Coffea pseudozanguebariae
Taxonomic Information:
Plant ID: NPO18807
Plant Latin Name: Coffea pseudozanguebariae
Taxonomy Genus: Coffea
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
49376
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HPGD; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2C9; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 6.212E-04 | 9.705E-01 | HPGD |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.212E-04 | 9.705E-01 | CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 4.141E-04 | 9.705E-01 | CYP2C9 |
| MF | GO:0005488; binding | GO:0048037; cofactor binding | 6.240E-04 | 9.705E-01 | CYP2C9, HPGD |
| BP | GO:0008152; metabolic process | GO:0070988; demethylation | 6.100E-03 | 1.000E+00 | CYP2C9 |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 7.854E-03 | 1.000E+00 | HPGD |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.917E-02 | 1.000E+00 | HPGD |
| MF | GO:0003824; catalytic activity | GO:0016614; oxidoreductase activity, acting on CH-OH group of donors | 1.403E-02 | 1.000E+00 | HPGD |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.650E-02 | 1.000E+00 | CYP2C9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.898E-03 | 1.228E-02 | CYP2C9 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 6.191E-03 | 1.228E-02 | CYP2C9 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 6.490E-03 | 1.228E-02 | CYP2C9 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 6.888E-03 | 1.228E-02 | CYP2C9 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 7.287E-03 | 1.228E-02 | CYP2C9 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.117E-02 | 1.436E-02 | CYP2C9 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 8.183E-03 | 1.228E-02 | CYP2C9 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.792E-02 | 2.016E-02 | HPGD |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.201E-01 | 1.201E-01 | CYP2C9 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
