CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 3 group C	NR3C1;
SLC superfamily of solute carriers	SLC1A2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
SLC superfamily of solute carriers	SLC1A2	Excitatory amino acid transporter 2	P43004	CHEMBL4973

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006352; DNA-templated transcription, initiation	2.111E-02	1.000E+00	NR3C1
BP	GO:0009987; cellular process	GO:0031668; cellular response to extracellular stimulus	2.193E-02	1.000E+00	SLC1A2
BP	GO:0050896; response to stimulus	GO:0048545; response to steroid hormone	2.255E-02	1.000E+00	NR3C1
BP	GO:0032502; developmental process	GO:0007568; aging	2.378E-02	1.000E+00	SLC1A2
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	2.521E-02	1.000E+00	NR3C1
BP	GO:0065007; biological regulation	GO:0001505; regulation of neurotransmitter levels	2.623E-02	1.000E+00	SLC1A2
BP	GO:0051179; localization	GO:0046942; carboxylic acid transport	2.766E-02	1.000E+00	SLC1A2
CC	GO:0044464; cell part	GO:0030673; axolemma	1.656E-03	1.000E+00	SLC1A2
CC	GO:0043226; organelle	GO:0016607; nuclear speck	3.784E-02	1.000E+00	NR3C1
MF	GO:0005215; transporter activity	GO:0015081; sodium ion transmembrane transporter activity	1.619E-02	1.000E+00	SLC1A2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.751E-02	2.751E-02	NR3C1
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.137E-02	1.705E-02	SLC1A2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	5.094E-03	1.528E-02	SLC1A2

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Endiandra anthropophagorum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities