CMAUP Plant Collective Molecular Activities

Plant Name: Endiandra anthropophagorum

Taxonomic Information:

Plant ID: NPO18777
Plant Latin Name: Endiandra anthropophagorum
Taxonomy Genus: Endiandra
Taxonomy Family: Lauraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 3 group C	NR3C1;
SLC superfamily of solute carriers	SLC1A2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
SLC superfamily of solute carriers	SLC1A2	Excitatory amino acid transporter 2	P43004	CHEMBL4973

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006352; DNA-templated transcription, initiation	2.111E-02	1.000E+00	NR3C1
BP	GO:0009987; cellular process	GO:0031668; cellular response to extracellular stimulus	2.193E-02	1.000E+00	SLC1A2
BP	GO:0050896; response to stimulus	GO:0048545; response to steroid hormone	2.255E-02	1.000E+00	NR3C1
BP	GO:0032502; developmental process	GO:0007568; aging	2.378E-02	1.000E+00	SLC1A2
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	2.521E-02	1.000E+00	NR3C1
BP	GO:0065007; biological regulation	GO:0001505; regulation of neurotransmitter levels	2.623E-02	1.000E+00	SLC1A2
BP	GO:0051179; localization	GO:0046942; carboxylic acid transport	2.766E-02	1.000E+00	SLC1A2
CC	GO:0044464; cell part	GO:0030673; axolemma	1.656E-03	1.000E+00	SLC1A2
CC	GO:0043226; organelle	GO:0016607; nuclear speck	3.784E-02	1.000E+00	NR3C1
MF	GO:0005215; transporter activity	GO:0015081; sodium ion transmembrane transporter activity	1.619E-02	1.000E+00	SLC1A2
MF	GO:0005488; binding	GO:0001047; core promoter binding	1.732E-02	1.000E+00	NR3C1
MF	GO:0005215; transporter activity	GO:0015291; secondary active transmembrane transporter activity	2.490E-02	1.000E+00	SLC1A2
MF	GO:0140110; transcription regulator activity	GO:0001077; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	2.807E-02	1.000E+00	NR3C1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	5.094E-03	1.528E-02	SLC1A2
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.137E-02	1.705E-02	SLC1A2
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.751E-02	2.751E-02	NR3C1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1;
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	NR3C1;
J00-J99: Diseases of the respiratory system	Asthma	J45	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1;
NA: NA	Non-infectious rhinitis	NA	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	NR3C1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	NR3C1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases