CMAUP Plant Collective Molecular Activities

Plant Name: Tectona grandis

Taxonomic Information:

Plant ID: NPO18640
Plant Latin Name: Tectona grandis
Taxonomy Genus: Tectona
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 41396
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Ghana; Philippines; Indonesia; India; Togo; China; Thailand

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM

Geographical Distribution:

Ghana; Philippines; Indonesia; India; Togo; China; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	TDP2; GLA; RECQL; IDO1;
Protein Kinase	MAPK1;
Lysine demethylase	KDM4E;
Hydrolase	MALT1;
Transcription Factor	NFKB1; TP53;
Unclassified	MAPT; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	TDP2	Tyrosyl-DNA phosphodiesterase 2	O95551	CHEMBL2169736
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Hydrolase	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	CHEMBL3632452
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	1.159E-01	CYP1A2, CYP2C19
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	1.751E-05	1.159E-01	RECQL, TP53
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.188E-05	1.159E-01	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0032769; negative regulation of monooxygenase activity	2.673E-05	1.159E-01	GLA, NFKB1
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.206E-05	1.159E-01	CYP1A2, CYP2C19
BP	GO:0002376; immune system process	GO:0002684; positive regulation of immune system process	4.231E-05	1.159E-01	IDO1, MALT1, MAPK1, NFKB1, THPO, TP53
BP	GO:0009987; cellular process	GO:0070234; positive regulation of T cell apoptotic process	4.417E-05	1.159E-01	IDO1, TP53
BP	GO:0050896; response to stimulus	GO:0006950; response to stress	4.441E-05	1.159E-01	CYP1A2, IDO1, MALT1, MAPK1, MAPT, NFKB1, RECQL, TDP2, TP53
BP	GO:0051704; multi-organism process	GO:0002237; response to molecule of bacterial origin	4.792E-05	1.159E-01	CYP1A2, IDO1, MALT1, NFKB1
MF	GO:0005488; binding	GO:0020037; heme binding	9.808E-05	1.844E-01	CYP1A2, CYP2C19, IDO1
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	1.824E-04	2.255E-01	MAPT, TP53
MF	GO:0005488; binding	GO:0019902; phosphatase binding	2.042E-04	2.255E-01	MAPK1, MAPT, TP53
CC	GO:0044464; cell part	GO:0005737; cytoplasm	6.764E-04	2.622E-01	GLA, MALT1, MAPK1, MAPT, NFKB1, NPSR1, RECQL, TDP2, TP53
MF	GO:0003824; catalytic activity	GO:0032451; demethylase activity	3.560E-04	2.622E-01	CYP1A2, KDM4E
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.744E-04	2.622E-01	CYP1A2, CYP2C19
MF	GO:0005488; binding	GO:0042802; identical protein binding	5.931E-04	2.622E-01	GLA, MALT1, MAPK1, MAPT, NFKB1, TP53
MF	GO:0005488; binding	GO:0043621; protein self-association	6.832E-04	2.622E-01	MALT1, TP53
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.050E-03	3.266E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0034774; secretory granule lumen	1.445E-03	3.578E-01	GLA, MAPK1, NFKB1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.217E-05	7.094E-04	MAPK1, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.650E-05	7.094E-04	MAPK1, NFKB1, MALT1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.650E-05	7.094E-04	MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.337E-05	7.536E-04	MAPK1, MAPT, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.993E-05	7.721E-04	MAPK1, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	4.769E-05	1.025E-03	MAPK1, NFKB1, MALT1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	7.306E-05	1.178E-03	MAPK1, TP53, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.155E-04	1.490E-03	MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	7.306E-05	1.178E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	9.919E-05	1.422E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.308E-04	1.534E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.554E-04	2.787E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	2.347E-04	2.163E-03	MAPK1, NFKB1, MALT1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	6.858E-04	4.364E-03	MAPK1, TP53
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.496E-04	2.787E-03	CYP1A2, IDO1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.828E-04	1.813E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	5.914E-04	4.238E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	7.104E-04	4.364E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	9.229E-04	4.961E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.045E-03	4.993E-03	MAPK1, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	1.813E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.673E-04	2.787E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	8.400E-04	4.926E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.555E-03	5.927E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	9.802E-04	4.993E-03	MAPK1, TP53
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	7.104E-04	4.364E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.100E-03	4.998E-03	MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.131E-03	4.998E-03	MAPK1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	4.993E-03	CYP1A2, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	9.229E-04	4.961E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.401E-03	7.461E-03	MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.162E-03	4.998E-03	MAPK1, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.209E-03	7.461E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.608E-03	5.927E-03	TP53, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.917E-03	6.684E-03	TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.226E-03	5.103E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.296E-03	7.461E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.464E-03	5.900E-03	CYP1A2, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	1.877E-03	6.684E-03	NFKB1, MALT1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.429E-03	7.461E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.340E-03	7.461E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.613E-03	7.838E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	1.608E-03	5.927E-03	MAPK1, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.707E-03	7.936E-03	MAPK1, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.999E-03	8.409E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.999E-03	8.409E-03	MAPK1, TP53
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	9.594E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	IDO1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	IDO1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases