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Plant Name: Tectona grandis




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 1.217E-05 7.094E-04 MAPK1; TP53; NFKB1
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.650E-05 7.094E-04 MAPK1; NFKB1; MALT1
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.650E-05 7.094E-04 MAPK1; TP53; NFKB1
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 2.337E-05 7.536E-04 MAPK1; MAPT; TP53; NFKB1
hsa05215 Prostate cancer_Homo sapiens_hsa05215 2.993E-05 7.721E-04 MAPK1; TP53; NFKB1
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 4.769E-05 1.025E-03 MAPK1; NFKB1; MALT1
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 7.306E-05 1.178E-03 MAPK1; TP53; NFKB1
hsa04210 Apoptosis_Homo sapiens_hsa04210 1.155E-04 1.490E-03 MAPK1; TP53; NFKB1
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 7.306E-05 1.178E-03 MAPK1; TP53; NFKB1
hsa05160 Hepatitis C_Homo sapiens_hsa05160 9.919E-05 1.422E-03 MAPK1; TP53; NFKB1
hsa05161 Hepatitis B_Homo sapiens_hsa05161 1.308E-04 1.534E-03 MAPK1; TP53; NFKB1
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 3.554E-04 2.787E-03 MAPK1; TP53; NFKB1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 2.347E-04 2.163E-03 MAPK1; NFKB1; MALT1
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 6.858E-04 4.364E-03 MAPK1; TP53
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 3.496E-04 2.787E-03 CYP1A2; IDO1
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.828E-04 1.813E-03 MAPK1; TP53
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 5.914E-04 4.238E-03 MAPK1; TP53
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 7.104E-04 4.364E-03 MAPK1; NFKB1
hsa05214 Glioma_Homo sapiens_hsa05214 9.229E-04 4.961E-03 MAPK1; TP53
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.045E-03 4.993E-03 MAPK1; TP53; NFKB1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 1.828E-04 1.813E-03 CYP1A2; CYP2C19
hsa05219 Bladder cancer_Homo sapiens_hsa05219 3.673E-04 2.787E-03 MAPK1; TP53
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 8.400E-04 4.926E-03 MAPK1; TP53
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 1.555E-03 5.927E-03 MAPK1; TP53; NFKB1
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 9.802E-04 4.993E-03 MAPK1; TP53
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 7.104E-04 4.364E-03 MAPK1; NFKB1
hsa05218 Melanoma_Homo sapiens_hsa05218 1.100E-03 4.998E-03 MAPK1; TP53
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 1.131E-03 4.998E-03 MAPK1; NFKB1
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 1.039E-03 4.993E-03 CYP1A2; CYP2C19
hsa05131 Shigellosis_Homo sapiens_hsa05131 9.229E-04 4.961E-03 MAPK1; NFKB1
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 2.401E-03 7.461E-03 MAPK1; TP53; NFKB1
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 1.162E-03 4.998E-03 MAPK1; NFKB1
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 2.209E-03 7.461E-03 MAPK1; NFKB1
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 1.608E-03 5.927E-03 TP53; NFKB1
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 1.917E-03 6.684E-03 TP53; NFKB1
hsa05133 Pertussis_Homo sapiens_hsa05133 1.226E-03 5.103E-03 MAPK1; NFKB1
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 2.296E-03 7.461E-03 MAPK1; NFKB1
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.464E-03 5.900E-03 CYP1A2; CYP2C19
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 1.877E-03 6.684E-03 NFKB1; MALT1
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 2.429E-03 7.461E-03 MAPK1; NFKB1
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 2.340E-03 7.461E-03 MAPK1; NFKB1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 2.613E-03 7.838E-03 MAPK1; NFKB1
hsa05132 Salmonella infection_Homo sapiens_hsa05132 1.608E-03 5.927E-03 MAPK1; NFKB1
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 2.707E-03 7.936E-03 MAPK1; CYP2C19
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 2.999E-03 8.409E-03 MAPK1; NFKB1
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 2.999E-03 8.409E-03 MAPK1; TP53
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 3.735E-03 1.004E-02 MAPK1; NFKB1
hsa05162 Measles_Homo sapiens_hsa05162 3.959E-03 1.042E-02 TP53; NFKB1
hsa05164 Influenza A_Homo sapiens_hsa05164 6.465E-03 1.635E-02 MAPK1; NFKB1
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 5.973E-03 1.541E-02 MAPK1; MAPT
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 8.528E-03 1.948E-02 TP53; NFKB1
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 6.827E-03 1.694E-02 TP53; NFKB1
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 7.349E-03 1.756E-02 MAPK1; NFKB1
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 8.609E-03 1.948E-02 MAPK1; TP53
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 7.198E-03 1.752E-02 TP53; NFKB1
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 8.286E-03 1.943E-02 MAPK1; NFKB1
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 1.067E-02 2.333E-02 MAPK1; NFKB1
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 1.362E-02 2.928E-02 TP53; NFKB1
hsa05143 African trypanosomiasis_Homo sapiens_hsa05143 2.423E-02 4.884E-02 IDO1
hsa05020 Prion diseases_Homo sapiens_hsa05020 2.423E-02 4.884E-02 MAPK1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 2.080E-02 4.328E-02 GLA
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 1.874E-02 3.963E-02 MAPK1
hsa00603 Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 9.759E-03 2.170E-02 GLA
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 3.495E-03 9.594E-03 CYP1A2
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT
C00-D49: Neoplasms Acute myeloid leukemia C92.0 TP53; TP53
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
E00-E89: Endocrine, nutritional and metabolic diseases Fabry's disease E75.2 GLA
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A TP53
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT
C00-D49: Neoplasms Colorectal cancer C18-C21 TP53
C00-D49: Neoplasms Solid tumours C00-D48 MAPK1; TP53
C00-D49: Neoplasms Hematological malignancies C81-C86 TP53
C00-D49: Neoplasms Cancer C00-C96 MAPK1; NFKB1; TP53; IDO1
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 TP53
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 IDO1
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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phacyz@nus.edu.sg

Developer & Maintainer:
Dr. Zeng Xian
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