CMAUP Plant Collective Molecular Activities

Plant Name: Prunus pseudocerasus

Taxonomic Information:

Plant ID: NPO18492
Plant Latin Name: Prunus pseudocerasus
Taxonomy Genus: Prunus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 151439
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3;
Enzyme_unclassified	HKDC1; USP2;
Lyase	CA1; CA9;
Oxidoreductase	MAOB;
Unclassified	MAPT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.020E-05	4.398E-01	CA1, CA9
BP	GO:0007610; behavior	GO:0007622; rhythmic behavior	1.021E-02	1.000E+00	USP2
CC	GO:0044464; cell part	GO:0005764; lysosome	6.758E-03	1.000E+00	NPC1, RAB9A
CC	GO:0044464; cell part	GO:0030673; axolemma	7.432E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	5.115E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034185; apolipoprotein binding	7.432E-03	1.000E+00	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.440E-05	8.051E-04	CA1, CA9
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	1.075E-02	5.252E-02	MAOB
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	7.626E-03	5.252E-02	MAOB
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	1.564E-02	5.252E-02	MAOB
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	2.248E-03	3.710E-02	HKDC1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.786E-02	5.252E-02	MAOB
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.342E-02	5.252E-02	HKDC1
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1.786E-02	5.252E-02	MAOB
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.431E-02	5.252E-02	HKDC1
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.184E-02	5.252E-02	MAOB

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Cancer	C00-C96	CA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases