CMAUP Plant Collective Molecular Activities

Plant Name: Peucedanum rubricaule

Taxonomic Information:

Plant ID: NPO17866
Plant Latin Name: Peucedanum rubricaule
Taxonomy Genus: Peucedanum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 516045
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Phosphodiesterase 4	PDE4D;
Lyase	CA1; CA7; CA12; CA9; CA13;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	XPO1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288
Unclassified	XPO1	Exportin-1	O14980	CHEMBL5661

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.059E-13	2.305E-09	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.321E-11	1.438E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.795E-11	2.755E-07	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.056E-09	1.104E-05	CA1, CA12, CA13, CA7, CA9, L3MBTL1, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.940E-05	2.640E-02	PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.832E-13	5.680E-12	CA12, CA1, CA7, CA9, CA13
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.998E-04	3.097E-03	PDE4D, PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	7.571E-04	7.824E-03	PPARA, PPARD
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.726E-02	8.875E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.368E-02	8.875E-02	PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.310E-02	8.875E-02	TSHR
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	3.135E-02	8.875E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	4.121E-02	8.875E-02	PPARA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.294E-02	8.875E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.179E-02	8.875E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases