CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.059E-13	2.305E-09	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.321E-11	1.438E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.795E-11	2.755E-07	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.056E-09	1.104E-05	CA1, CA12, CA13, CA7, CA9, L3MBTL1, PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.832E-13	5.680E-12	CA12; CA1; CA7; CA9; CA13
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.998E-04	3.097E-03	PDE4D; PPARA; TSHR
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	7.571E-04	7.824E-03	PPARA; PPARD

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Renal cancer	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; XPO1
J00-J99: Diseases of the respiratory system	Emphysema	J43	PDE4D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Breast cancer	C50	CA9
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1
NA: NA	Dyslipidemia	NA	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	PDE4D
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE4D; PDE4D
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; XPO1
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	PDE4D
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE4D; PDE4D; PDE4D
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PDE4D

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Peucedanum rubricaule

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases