Plant Name: Hemerocallis fulva
Taxonomic Information:
Plant ID: NPO17774
Plant Latin Name: Hemerocallis fulva
Taxonomy Genus: Hemerocallis
Taxonomy Family: Xanthorrhoeaceae
Plant External Links:
NCBI TaxonomyDB:
34190
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Anodyne; Anthelmintic; Antidote; Antiemetic; Antispasmodic; Blood purifier; Cancer; Depurative; Diuretic; Febrifuge; Laxative; Sedative
Geographical Distribution:
India; China
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ATP1A1; | |
| RECQL; TDP1; PTGES; | |
| MAPK1; | |
| CA12; CA7; | |
| RORC; | |
| PREP; | |
| TP53; STAT3; | |
| KMT2A; | |
| SLCO4C1; SLCO1B1; | |
| LMNA; RAB9A; NPC1; MAPT; PAX8; MITF; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Hydrolase | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain | P05023 | CHEMBL1807 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Plant homeodomain | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Serine protease | PREP | Prolyl endopeptidase | P48147 | CHEMBL3202 |
| SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | STAT3 | Signal transducer and activator of transcription 3 | P40763 | CHEMBL4026 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | MITF | Microphthalmia-associated transcription factor | O75030 | CHEMBL1741165 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005496; steroid binding | 2.520E-06 | 5.246E-02 | ATP1A1, CYP3A4, NPC1, RORC |
| MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 7.228E-06 | 5.246E-02 | KMT2A, MITF, PAX8, TP53 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 2.365E-05 | 6.839E-02 | KMT2A, MAPK1, MAPT, NPC1, STAT3, TP53 |
| BP | GO:0050896; response to stimulus | GO:0010038; response to metal ion | 2.489E-05 | 6.839E-02 | KMT2A, MAPK1, NPC1, PTGES, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 3.931E-05 | 7.782E-02 | ATP1A1, MAPK1, NPC1, RORC, STAT3 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 3.252E-05 | 7.782E-02 | MAPK1, MAPT, STAT3, TP53 |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 4.436E-05 | 8.050E-02 | RECQL, TP53 |
| BP | GO:0009987; cellular process | GO:0051716; cellular response to stimulus | 4.936E-05 | 8.268E-02 | ATP1A1, LMNA, MAPK1, MAPT, NPC1, PAX8, RECQL, RORC, STAT3, TDP1, TP53 |
| BP | GO:0065007; biological regulation | GO:0048878; chemical homeostasis | 5.936E-05 | 9.233E-02 | ATP1A1, CA12, CA7, MAPK1, NPC1, STAT3, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.289E-04 | 1.233E-01 | CA12, CA7 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.182E-03 | 2.848E-01 | ATP1A1, SLCO1B1, SLCO4C1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 2.618E-03 | 3.931E-01 | MAPK1, MAPT |
| CC | GO:0016020; membrane | GO:0005901; caveola | 2.934E-03 | 4.199E-01 | ATP1A1, MAPK1 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 3.548E-03 | 4.199E-01 | ATP1A1, CYP3A4, KMT2A, LMNA, MAPK1, MAPT, MITF, NPC1, PAX8, PREP, RAB9A, RECQL, RORC, STAT3, TDP1, TP53 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 3.926E-03 | 4.443E-01 | KMT2A, LMNA, MAPK1, MITF, PAX8, RECQL, RORC, STAT3, TP53 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 4.297E-03 | 4.500E-01 | ATP1A1, MAPK1, NPC1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 9.487E-05 | 2.277E-03 | PAX8, STAT3, MITF, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 8.368E-05 | 2.277E-03 | STAT3, RAB9A, TP53 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.275E-05 | 2.277E-03 | CA12, CA7 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.568E-04 | 2.822E-03 | PAX8, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 8.172E-04 | 9.720E-03 | STAT3, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 9.450E-04 | 9.720E-03 | MITF, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 9.450E-04 | 9.720E-03 | PAX8, ATP1A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| NA: NA | Arrhythmias | NA | ATP1A1; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | ATP1A1; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | STAT3; TP53; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| C00-D49: Neoplasms | Cancer | C00-C96 | STAT3; ATP1A1; TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | STAT3; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ATP1A1; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | STAT3; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperhidrosis | R61 | ATP1A1; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | ATP1A1; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| NA: NA | Congestive cardiac insufficiency | NA | ATP1A1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ATP1A1; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | ATP1A1; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ATP1A1; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | STAT3; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
