Plant Name: Hemerocallis fulva
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 4.760E-06 | 6.331E-04 | PAX8; MAPK1; TP53 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 5.798E-05 | 2.003E-03 | STAT3; MAPK1; TP53 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 7.529E-05 | 2.003E-03 | PAX8; STAT3; MAPK1; MITF; TP53 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 7.215E-05 | 2.003E-03 | MAPK1; MITF; TP53 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 7.215E-05 | 2.003E-03 | SLCO1B1; ATP1A1; CYP3A4 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 3.253E-04 | 6.180E-03 | MAPK1; ATP1A1; TP53 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 5.365E-04 | 7.136E-03 | LMNA; MAPK1; TP53 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 4.619E-04 | 7.136E-03 | STAT3; MAPK1; TP53 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 4.930E-04 | 7.136E-03 | STAT3; RAB9A; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 6.063E-04 | 7.331E-03 | STAT3; MAPK1; TP53 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.571E-03 | 1.267E-02 | STAT3; MAPK1; TP53 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.616E-03 | 1.267E-02 | STAT3; MAPK1; TP53 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.112E-03 | 1.056E-02 | KMT2A; PAX8; TP53 |
| hsa04960 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 9.135E-04 | 1.012E-02 | MAPK1; ATP1A1 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 1.009E-03 | 1.033E-02 | MAPK1; TP53 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.876E-03 | 1.360E-02 | MAPK1; TP53 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.703E-04 | 3.774E-03 | CA12; CA7 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 1.620E-03 | 1.267E-02 | MAPK1; TP53 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.943E-03 | 1.360E-02 | STAT3; MAPK1 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 3.004E-03 | 1.558E-02 | MAPK1; MAPT; TP53 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 2.518E-03 | 1.522E-02 | MAPK1; TP53 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 2.294E-03 | 1.522E-02 | MAPK1; TP53 |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.518E-03 | 1.522E-02 | STAT3; RORC |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 4.607E-03 | 2.138E-02 | STAT3; MAPK1; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 2.673E-03 | 1.546E-02 | MAPK1; TP53 |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 3.079E-03 | 1.558E-02 | STAT3; MAPK1 |
| hsa04918 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 2.996E-03 | 1.558E-02 | PAX8; ATP1A1 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 3.164E-03 | 1.558E-02 | MAPK1; TP53 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 5.962E-03 | 2.558E-02 | STAT3; MAPK1 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 4.662E-03 | 2.138E-02 | MAPK1; TP53 |
| hsa04916 | Melanogenesis_Homo sapiens_hsa04916 | 5.848E-03 | 2.558E-02 | MAPK1; MITF |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 6.193E-03 | 2.574E-02 | STAT3; MAPK1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 8.053E-03 | 3.161E-02 | STAT3; MAPK1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 8.318E-03 | 3.161E-02 | MAPK1; TP53 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 9.989E-03 | 3.643E-02 | MAPK1; MITF |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 8.318E-03 | 3.161E-02 | MAPK1; TP53 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.013E-02 | 3.643E-02 | STAT3; MAPK1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.149E-02 | 4.020E-02 | STAT3; MAPK1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.243E-02 | 4.238E-02 | MAPK1; ATP1A1 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| NA: NA | Arrhythmias | NA | ATP1A1; ATP1A1 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | PREP |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | ATP1A1; ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | PREP |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; MAPK1; STAT3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; PREP |
| C00-D49: Neoplasms | Cancer | C00-C96 | ATP1A1; TP53; MAPK1; STAT3 |
| K00-K95: Diseases of the digestive system | Celiac disease | K90.0 | PREP |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | STAT3 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ATP1A1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | STAT3 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | PREP |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperhidrosis | R61 | ATP1A1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PTGES; MAPT |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | ATP1A1 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| NA: NA | Congestive cardiac insufficiency | NA | ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ATP1A1 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | ATP1A1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ATP1A1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Multiple myeloma | C90 | STAT3 |