CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR4; FFAR1;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15;
Oxidoreductase	PTGS2; ALOX5;
Unclassified	FABP3; FABP5; FABP4; LMNA; MPEG1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	1.021E-07	5.559E-04	ALOX15, ALOX5, PTGS2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.181E-07	1.434E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	1.407E-06	2.251E-03	ALOX15, ALOX5, PTGS2
BP	GO:0009987; cellular process	GO:0071248; cellular response to metal ion	1.562E-06	2.267E-03	ALOX15, FABP4, MAPK1, PTGS2
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	5.300E-06	5.246E-03	ALOX15, ALOX5
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.487E-09	3.237E-05	FABP3, FABP4, FABP5, FFAR4
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.061E-06	1.925E-03	ALOX15, PTGS2

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.118E-06	2.101E-04	ALOX5, ALOX15, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.289E-08	6.477E-06	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.456E-07	2.295E-05	ALOX5, ALOX15, MAPK1, PTGS2

Showing 1 to 3 of 3 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2; ALOX5;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2; ALOX5;

Showing 1 to 10 of 41 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aegiceras corniculatum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities