Plant Name: Aegiceras corniculatum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| FFAR1; FFAR4; | |
| FAAH; TDP1; TERT; HPGD; ALOX12; ALOX15; ALDH1A1; USP2; | |
| MAPK1; | |
| PPARA; PPARD; PPARG; | |
| NR1I2; | |
| ALOX5; PTGS1; PTGS2; | |
| TLR2; | |
| XIAP; | |
| KAT2B; | |
| ABCB1; | |
| LMNA; FABP3; FABP5; FABP2; FABP4; MPEG1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Bromodomain | KAT2B | Histone acetyltransferase PCAF | Q92831 | CHEMBL5500 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group I | NR1I2 | Pregnane X receptor | O75469 | CHEMBL3401 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transferase | XIAP | Inhibitor of apoptosis protein 3 | P98170 | CHEMBL4198 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | MPEG1 | Macrophage-expressed gene 1 protein | Q2M385 | CHEMBL3414409 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 2.290E-11 | 7.123E-08 | ALOX12, ALOX15, ALOX5, HPGD, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.070E-08 | 4.600E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.179E-07 | 7.686E-05 | FABP3, FFAR1, PPARG, PTGS2, TLR2 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.253E-07 | 7.686E-05 | ALOX12, ALOX15, ALOX5, TLR2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 8.283E-07 | 3.681E-04 | NR1I2, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.761E-06 | 6.972E-04 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.855E-06 | 7.088E-04 | FABP3, KAT2B, PPARA, PPARG, TLR2 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.176E-06 | 7.405E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 2.176E-06 | 7.405E-04 | PTGS1, PTGS2 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.176E-06 | 7.405E-04 | ALOX12, ALOX15 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.941E-06 | 9.559E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 3.704E-06 | 1.169E-03 | KAT2B, NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 6.507E-06 | 1.894E-03 | FABP3, KAT2B, LMNA, PPARD, PPARG, PTGS2, TERT, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 6.523E-06 | 1.894E-03 | ALOX15, PTGS2 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.523E-06 | 1.894E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 6.523E-06 | 1.894E-03 | ALOX12, ALOX15 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.698E-05 | 4.108E-03 | LMNA, PPARD, PTGS2, TERT |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 2.170E-05 | 5.028E-03 | ALOX12, ALOX15 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 2.170E-05 | 5.028E-03 | PPARA, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.524E-05 | 5.725E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 3.252E-05 | 7.082E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 3.252E-05 | 7.082E-03 | PPARA, PPARG |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 3.252E-05 | 7.082E-03 | FABP3, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 4.083E-05 | 8.549E-03 | NR1I2, PPARA, PPARD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.252E-12 | 7.940E-10 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.152E-08 | 7.317E-07 | ALOX5; ALOX15; MAPK1; ALOX12; PTGS2; PTGS1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.723E-08 | 1.153E-06 | ALOX5; ALOX15; ALOX12; PTGS2; PTGS1 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.243E-06 | 3.945E-05 | FABP4; PTGS2; TSHR; PTGS1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 2.440E-05 | 6.197E-04 | ALOX5; XIAP; MAPK1; TLR2 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 2.409E-04 | 4.371E-03 | XIAP; MAPK1; PPARG; PTGS2; PPARD |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 1.592E-04 | 3.370E-03 | MAPK1; PTGS2; TLR2 |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 4.152E-04 | 6.591E-03 | FAAH; MAPK1; PTGS2 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.074E-03 | 1.363E-02 | LMNA; XIAP; MAPK1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.930E-03 | 3.013E-02 | MAPK1; PPARA; TSHR |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 8.044E-04 | 1.135E-02 | MAPK1; PPARG |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 2.382E-03 | 2.750E-02 | ALOX5; PTGS2 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 3.084E-03 | 3.013E-02 | MAPK1; PPARD |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 3.523E-03 | 3.196E-02 | MAPK1; PTGS2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; PPARD; PTGS2; PPARG; PPARG |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5; PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; PPARG |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ALOX5; PTGS1; FAAH; PTGS2 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Ankylosing spondylitis | M08.1, M45 | PTGS2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | FAAH |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | FAAH |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2; TERT |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PTGS2; PPARG |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; MAPK1; TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | FAAH |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | ALOX5 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PTGS2; PPARG; PPARG |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | ALOX5; PTGS2; PTGS2; PTGS2; PTGS2 |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; PPARG |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | FAAH |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Hyperthermia | T68 | PTGS2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Knee osteoarthritis | M15-M19, M47 | PTGS2 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | XIAP |
| C00-D49: Neoplasms | Ovarian cancer | C56 | ABCB1; TERT |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ALOX5 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | PTGS2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TLR2; TERT; PTGS2 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS1; FAAH; PTGS2; PTGS2; PTGS2; PTGS2 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1; PTGS2; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5; PTGS2 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | TLR2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | PTGS1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; PPARD; NR1I2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ALOX5; PTGS2; PTGS2 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ALOX5; ALOX5; PTGS2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2; TERT |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | ALOX5 |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1; PTGS2; PTGS2 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | XIAP; PPARD; PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; PPARG |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; PTGS2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | ABCB1; XIAP; MAPK1; TLR2; PTGS2 |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| NA: NA | Rheumatold arthritis | NA | PTGS1; PTGS2; PTGS2; PTGS2 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1 |
| K00-K95: Diseases of the digestive system | Colon polyps | K63.5 | PTGS2 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| NA: NA | Joint and muscular pain | NA | PTGS2 |
| NA: NA | Miosis during ocular surgery | NA | PTGS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Moderate to severe rheumatoid arthritis | M05-M06 | PTGS2 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PTGS2; PPARG |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1; PTGS2; PTGS2; PTGS2; PTGS2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |