CMAUP Plant Collective Molecular Activities

Plant Name: Amorpha fruticosa

Taxonomic Information:

Plant ID: NPO16886
Plant Latin Name: Amorpha fruticosa
Taxonomy Genus: Amorpha
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 48131
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARG;
Enzyme_unclassified	ALDH1A1;
Transcription Factor	TP53;
Unclassified	MAPT; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	5.978E-05	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.143E-07	2.533E-03	CYP2C19, CYP2C9, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	5.238E-03	CYP2C19, CYP2C9, CYP2D6
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.946E-06	6.285E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	4.417E-06	6.412E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	4.417E-06	6.412E-03	PPARA, PPARG
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	6.182E-06	7.918E-03	PPARA, TP53
BP	GO:0007610; behavior	GO:0007610; behavior	6.736E-06	8.149E-03	GAA, MAPK1, MAPT, PPARA, TP53
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.991E-05	2.069E-02	CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	4.511E-05	2.183E-02	CYP2C19, CYP2C9, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.983E-07	2.580E-05	CYP2C9, CYP2D6, MAPK1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	4.487E-07	2.580E-05	MAPK1, PPARG, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.357E-06	2.437E-04	CYP2C9, CYP2D6, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	4.562E-05	1.312E-03	MAPK1, PPARA, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.133E-04	4.282E-03	MAPK1, MAPT, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.229E-04	4.272E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.167E-04	4.282E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	3.592E-04	4.282E-03	MAPK1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.108E-04	2.547E-03	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	5.613E-04	4.282E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	5.108E-04	4.282E-03	MAPK1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.108E-04	4.282E-03	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	5.787E-04	4.282E-03	MAPK1, TP53
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.613E-04	4.282E-03	CYP2C9, ALDH1A1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.138E-03	5.847E-03	MAPK1, PPARG, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.963E-04	4.282E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.694E-04	4.282E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.075E-04	4.282E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.049E-03	5.746E-03	MAPK1, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	4.282E-03	CYP2C9, CYP2D6
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.323E-04	4.282E-03	PPARG, PPARA
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.169E-03	5.847E-03	PPARG, TP53
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.917E-04	5.127E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.833E-03	8.383E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.895E-03	8.383E-03	MAPK1, TP53
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.287E-03	9.740E-03	MAPK1, PPARG
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.895E-03	8.383E-03	MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.425E-03	9.960E-03	RAB9A, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	PPARG;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG;
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARG;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PPARG;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARG;
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARG;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARG;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases