Plant Name: Amorpha fruticosa
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.745E-09 | 5.978E-05 | CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 8.143E-07 | 2.533E-03 | CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.924E-06 | 5.238E-03 | CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 2.946E-06 | 6.285E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 4.417E-06 | 6.412E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 4.417E-06 | 6.412E-03 | PPARA, PPARG |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 6.182E-06 | 7.918E-03 | PPARA, TP53 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 6.736E-06 | 8.149E-03 | GAA, MAPK1, MAPT, PPARA, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.983E-07 | 2.580E-05 | CYP2C9; CYP2D6; MAPK1; CYP2C19 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 4.487E-07 | 2.580E-05 | MAPK1; PPARG; TP53 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 6.357E-06 | 2.437E-04 | CYP2C9; CYP2D6; CYP2C19 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 4.562E-05 | 1.312E-03 | MAPK1; PPARA; TP53 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 3.133E-04 | 4.282E-03 | MAPK1; MAPT; TP53 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.229E-04 | 4.272E-03 | MAPK1; TP53 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 4.167E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 3.592E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.108E-04 | 2.547E-03 | CYP2C9; CYP2C19 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 5.613E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 5.108E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 5.108E-04 | 4.282E-03 | CYP2C9; CYP2C19 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 5.787E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.613E-04 | 4.282E-03 | CYP2C9; ALDH1A1 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.138E-03 | 5.847E-03 | MAPK1; PPARG; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 5.963E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 6.694E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 7.075E-04 | 4.282E-03 | MAPK1; TP53 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.049E-03 | 5.746E-03 | MAPK1; TP53 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.075E-04 | 4.282E-03 | CYP2C9; CYP2D6 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.323E-04 | 4.282E-03 | PPARG; PPARA |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.169E-03 | 5.847E-03 | PPARG; TP53 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 8.917E-04 | 5.127E-03 | CYP2C9; CYP2C19 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.833E-03 | 8.383E-03 | MAPK1; TP53 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.895E-03 | 8.383E-03 | MAPK1; TP53 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.567E-03 | 1.018E-02 | MAPK1; TP53 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.287E-03 | 9.740E-03 | MAPK1; PPARG |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.402E-03 | 1.262E-02 | CYP2C9; GAA; ALDH1A1; CYP2C19 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.895E-03 | 8.383E-03 | MAPK1; TP53 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 2.425E-03 | 9.960E-03 | RAB9A; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 2.788E-03 | 1.069E-02 | MAPK1; TP53 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 3.670E-03 | 1.319E-02 | MAPK1; MAPT |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 5.309E-03 | 1.682E-02 | MAPK1; TP53 |
| hsa05016 | Huntington's disease_Homo sapiens_hsa05016 | 4.812E-03 | 1.627E-02 | PPARG; TP53 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 5.107E-03 | 1.678E-02 | MAPK1; PPARA |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 5.411E-03 | 1.682E-02 | MAPK1; TP53 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 4.200E-03 | 1.464E-02 | PPARG; TP53 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.440E-02 | 4.242E-02 | MAPK1; TP53 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.106E-02 | 3.348E-02 | MAPK1; TP53 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.638E-02 | 4.595E-02 | GAA |
| hsa04320 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.475E-02 | 4.242E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; PPARG; PPARG |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; TP53 |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | PPARG |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PPARG |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARG |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PPARG |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PPARG; PPARG |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |