CMAUP Plant Collective Molecular Activities

Plant Name: Salvia castanea

Taxonomic Information:

Plant ID: NPO16750
Plant Latin Name: Salvia castanea
Taxonomy Genus: Salvia
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 476450
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	CES1; ALPL; TDP1; HSD17B10; CES2;
Hydrolase	GAA; ACHE;
Protein Phosphatase	PTPN11; PTPN6;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA4; CA6;
Transcription Factor	TP53; NFKB1;
Unclassified	RAB9A; MAPT; PFKFB3;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Protein Phosphatase	PTPN6	Protein-tyrosine phosphatase 1C	P29350	CHEMBL3166
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	CHEMBL2331053

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.693E-14	1.466E-10	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.318E-08	8.548E-05	CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.906E-07	6.075E-04	CES1, CES2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	1.742E-06	2.371E-03	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	6.318E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	5.222E-06	6.318E-03	CES1, CES2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.563E-06	8.668E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.083E-20	4.535E-16	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.599E-16	6.096E-12	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.260E-05	1.098E-02	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.605E-05	2.101E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.947E-20	6.066E-18	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.853E-05	1.455E-03	XDH, CES2, CES1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9.653E-05	2.912E-03	CYP2C9, CYP2D6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.142E-04	2.912E-03	PTPN11, TP53, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.046E-04	6.879E-03	CYP2C9, CYP2D6, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	4.952E-04	7.215E-03	PTPN11, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.979E-04	8.139E-03	CYP2C9, GAA, ALPL, CYP2C19, HSD17B10, XDH, CES1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	7.131E-04	8.082E-03	RAB9A, TP53, NFKB1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	6.879E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	6.457E-04	8.082E-03	CYP2C9, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	CES1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Upper abdominal bloating	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
NA: NA	Edema	NA	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	CES1;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	CES1;
C00-D49: Neoplasms	Solid tumours	C00-D48	PFKFB3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases