Plant Name: Salvia castanea
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.693E-14 | 1.466E-10 | CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.318E-08 | 8.548E-05 | CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 3.906E-07 | 6.075E-04 | CES1, CES2, CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0009987; cellular process | GO:0033277; abortive mitotic cell cycle | 1.742E-06 | 2.371E-03 | PTPN11, PTPN6 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 5.222E-06 | 6.318E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0047374; methylumbelliferyl-acetate deacetylase activity | 5.222E-06 | 6.318E-03 | CES1, CES2 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.563E-06 | 8.668E-03 | CA1, CA12, CA2, CA4, CA6, CA7, CA9, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.083E-20 | 4.535E-16 | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 5.599E-16 | 6.096E-12 | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 5.947E-20 | 6.066E-18 | CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.853E-05 | 1.455E-03 | XDH; CES2; CES1 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 9.653E-05 | 2.912E-03 | CYP2C9; CYP2D6; CYP2C19 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.142E-04 | 2.912E-03 | PTPN11; TP53; NFKB1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.046E-04 | 6.879E-03 | CYP2C9; CYP2D6; CYP2C19 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 4.952E-04 | 7.215E-03 | PTPN11; TP53; NFKB1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 7.979E-04 | 8.139E-03 | CYP2C9; GAA; ALPL; CYP2C19; HSD17B10; XDH; CES1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 7.131E-04 | 8.082E-03 | RAB9A; TP53; NFKB1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 4.043E-04 | 6.879E-03 | CA2; CA4 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.255E-03 | 1.917E-02 | PTPN6; PTPN11; TP53 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.731E-03 | 1.605E-02 | PTPN11; TP53; NFKB1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 6.457E-04 | 8.082E-03 | CYP2C9; CYP2C19 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.929E-03 | 2.166E-02 | CYP2C9; CYP2C19 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 3.312E-03 | 2.166E-02 | TP53; NFKB1 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 4.288E-03 | 2.187E-02 | MAPT; TP53; NFKB1 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 3.512E-03 | 2.166E-02 | PTPN11; NFKB1 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 4.035E-03 | 2.166E-02 | PTPN6; NFKB1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 3.717E-03 | 2.166E-02 | PTPN11; NFKB1 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 4.035E-03 | 2.166E-02 | PTPN6; NFKB1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 4.035E-03 | 2.166E-02 | CYP2C9; CYP2D6 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 5.937E-03 | 2.633E-02 | TP53; NFKB1 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 5.554E-03 | 2.575E-02 | TP53; NFKB1 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 6.600E-03 | 2.693E-02 | TP53; NFKB1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 5.063E-03 | 2.459E-02 | CYP2C9; CYP2C19 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 7.876E-03 | 3.031E-02 | PFKFB3; NFKB1 |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 8.024E-03 | 3.031E-02 | PTPN6; NFKB1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 8.783E-03 | 3.199E-02 | PTPN11; NFKB1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.417E-02 | 4.515E-02 | TP53; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.056E-02 | 3.715E-02 | TP53; NFKB1 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 1.285E-02 | 4.350E-02 | TP53; NFKB1 |
| hsa04650 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.322E-02 | 4.350E-02 | PTPN6; PTPN11 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.534E-02 | 4.741E-02 | TP53; NFKB1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 6.484E-03 | 2.693E-02 | XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; ACHE |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; ACHE; CA4 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; CA1; CA9; NFKB1; ACHE |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | CES1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | CES1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1; ACHE |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; MAPT |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; MAPT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; CYP2D6 |
| NA: NA | Edema | NA | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CES1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; ACHE; ACHE; MAPT |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| I00-I99: Diseases of the circulatory system | Peripheral vascular disease | I73.9 | CES1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | CES1 |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | CES1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; CA9; PFKFB3 |