Plant Name: Iris sibirica
Taxonomic Information:
Plant ID: NPO16727
Plant Latin Name: Iris sibirica
Taxonomy Genus: Iris
Taxonomy Family: Iridaceae
Plant External Links:
NCBI TaxonomyDB:
198826
Plant-of-the-World-Online:
439087-1
Used in Medicines:
Unknown.
Geographical Distribution:
Canada; Turkey; Romania; Belarus; Italy; South Africa; Poland; Ukraine; Sweden; Mongolia; France; United States; Austria; Germany; Switzerland; Hungary; Kazakhstan; Russia; Bulgaria
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HKDC1; USP2; | |
| MAOB; | |
| MAPT; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0048699; generation of neurons | 2.483E-03 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 2.483E-03 | 1.000E+00 | MAOB |
| BP | GO:0009987; cellular process | GO:1990000; amyloid fibril formation | 2.483E-03 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0042420; dopamine catabolic process | 2.483E-03 | 1.000E+00 | MAOB |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 2.793E-03 | 1.000E+00 | MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 2.793E-03 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0032930; positive regulation of superoxide anion generation | 4.341E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0071404; cellular response to low-density lipoprotein particle stimulus | 4.341E-03 | 1.000E+00 | NPC1 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 4.341E-03 | 1.000E+00 | NPC1 |
| BP | GO:0002376; immune system process | GO:0001774; microglial cell activation | 5.270E-03 | 1.000E+00 | MAPT |
| BP | GO:0050896; response to stimulus | GO:0043153; entrainment of circadian clock by photoperiod | 5.888E-03 | 1.000E+00 | USP2 |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 7.433E-03 | 1.000E+00 | NPC1 |
| BP | GO:0007610; behavior | GO:0007628; adult walking behavior | 8.359E-03 | 1.000E+00 | NPC1 |
| BP | GO:0032501; multicellular organismal process | GO:0032922; circadian regulation of gene expression | 1.697E-02 | 1.000E+00 | USP2 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 1.727E-02 | 1.000E+00 | NPC1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 2.033E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0071383; cellular response to steroid hormone stimulus | 2.277E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:1901216; positive regulation of neuron death | 2.368E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 2.399E-02 | 1.000E+00 | MAPT |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.521E-02 | 1.000E+00 | MAPT |
| BP | GO:0007610; behavior | GO:0007613; memory | 3.218E-02 | 1.000E+00 | MAPT |
| BP | GO:0050896; response to stimulus | GO:0045471; response to ethanol | 3.550E-02 | 1.000E+00 | MAOB |
| BP | GO:0008152; metabolic process | GO:0031324; negative regulation of cellular metabolic process | 3.766E-02 | 1.000E+00 | MAPT, NPC1, USP2 |
| BP | GO:0009987; cellular process | GO:0050808; synapse organization | 4.361E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 4.391E-02 | 1.000E+00 | USP2 |
| BP | GO:0008152; metabolic process | GO:0019318; hexose metabolic process | 4.660E-02 | 1.000E+00 | HKDC1 |
| BP | GO:0008152; metabolic process | GO:0022900; electron transport chain | 4.928E-02 | 1.000E+00 | MAOB |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.896E-03 | 1.000E+00 | NPC1, RAB9A |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 4.960E-03 | 1.000E+00 | MAPT |
| CC | GO:0044464; cell part | GO:0048471; perinuclear region of cytoplasm | 1.536E-02 | 1.000E+00 | NPC1, USP2 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 2.063E-02 | 1.000E+00 | MAPT |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 3.097E-02 | 1.000E+00 | RAB9A |
| CC | GO:0044421; extracellular region part | GO:0070062; extracellular exosome | 4.364E-02 | 1.000E+00 | MAOB, NPC1, RAB9A |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.958E-02 | 1.000E+00 | NPC1 |
| MF | GO:0003824; catalytic activity | GO:0008131; primary amine oxidase activity | 1.863E-03 | 1.000E+00 | MAOB |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 3.412E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 4.960E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 8.667E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0030332; cyclin binding | 9.592E-03 | 1.000E+00 | USP2 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 9.900E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0042803; protein homodimerization activity | 2.273E-02 | 1.000E+00 | MAOB, MAPT |
| MF | GO:0005488; binding | GO:0050660; flavin adenine dinucleotide binding | 2.277E-02 | 1.000E+00 | MAOB |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 3.309E-02 | 1.000E+00 | MAOB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00524 | Butirosin and neomycin biosynthesis | 1.499E-03 | 3.307E-02 | HKDC1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 7.179E-03 | 3.307E-02 | MAOB |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 5.090E-03 | 3.307E-02 | MAOB |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 1.046E-02 | 3.307E-02 | MAOB |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 1.668E-02 | 3.307E-02 | HKDC1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00520 | Amino sugar and nucleotide sugar metabolism | 1.432E-02 | 3.307E-02 | HKDC1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 1.491E-02 | 3.307E-02 | MAOB |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00010 | Glycolysis / Gluconeogenesis | 1.993E-02 | 3.307E-02 | HKDC1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.993E-02 | 3.307E-02 | HKDC1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.052E-02 | 3.307E-02 | MAOB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
