CMAUP Plant Collective Molecular Activities

Plant Name: Iris sibirica

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT; MAOB
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; MAOB
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOB; MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB
NA: NA	Motor symptoms	NA	MAOB
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT; MAOB
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases