Plant Name: Cirsium chinense
Taxonomic Information:
Plant ID: NPO16682
Plant Latin Name: Cirsium chinense
Taxonomy Genus: Cirsium
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; | |
| TDP1; | |
| APP; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0014005; microglia development | 4.659E-04 | 6.441E-01 | APP |
| MF | GO:0005488; binding | GO:0051425; PTB domain binding | 6.212E-04 | 6.441E-01 | APP |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 1.242E-03 | 7.955E-01 | APP |
| MF | GO:0060089; molecular transducer activity | GO:0001609; G-protein coupled adenosine receptor activity | 1.087E-03 | 7.955E-01 | ADORA3 |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 4.482E-02 | 1.000E+00 | APP |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 4.903E-02 | 1.000E+00 | APP |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | APP |
| MF | GO:0098772; molecular function regulator | GO:0016504; peptidase activator activity | 5.736E-03 | 1.000E+00 | APP |
| MF | GO:0005488; binding | GO:0003677; DNA binding | 4.580E-02 | 1.000E+00 | APP, TDP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.671E-02 | 3.124E-02 | APP |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.789E-02 | 3.124E-02 | ADORA3 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04022 | cGMP-PKG signaling pathway | 2.484E-02 | 3.124E-02 | ADORA3 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 3.124E-02 | APP |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 4.098E-02 | 4.098E-02 | ADORA3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
