CMAUP Plant Collective Molecular Activities

Plant Name: Astrantia major

Taxonomic Information:

Plant ID: NPO16642
Plant Latin Name: Astrantia major
Taxonomy Genus: Astrantia
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 52448
Plant-of-the-World-Online: 838340-1

Used in Medicines:

Country/Region:

Albania; China

Traditional Medicine System:

TCM

Medicinal Functions:

Diuretic; Purgative

Geographical Distribution:

Ukraine; Romania; Belarus; Italy; Denmark; Poland; Finland; France; United Kingdom; Switzerland; Austria; Albania; China; Hungary; Belgium; Germany; Spain; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Enzyme_unclassified	TDP1; RECQL; PKM; AKR1B1; POLB; APEX1;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP1;
Unclassified	MCL1; MAPT; LMNA; TTR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	4.878E-07	6.371E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.463E-06	6.371E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.463E-06	6.371E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	2.962E-06	1.075E-02	AKR1B1, APEX1, LMNA, MAPT, MCL1, POLB, RECQL, TDP1
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	1.022E-05	2.226E-02	PKM, TTR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.957E-04	3.797E-03	GAA, AKR1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	2.373E-04	3.797E-03	POLB, APEX1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.190E-03	4.469E-02	LMNA, MCL1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	8.773E-03	7.019E-02	POLB, PKM
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.492E-02	9.187E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2.765E-02	9.187E-02	PKM
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.725E-02	9.187E-02	MMP1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.858E-02	9.187E-02	NR1H4
Unclassified	Unclassified	hsa01230	Biosynthesis of amino acids	5.059E-02	9.187E-02	PKM
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	5.059E-02	9.187E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Solid tumours	C00-D48	PKM;
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases