CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	4.878E-07	6.371E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.463E-06	6.371E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.463E-06	6.371E-03	GPBAR1, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.957E-04	3.797E-03	GAA; AKR1B1
hsa03410	Base excision repair_Homo sapiens_hsa03410	2.373E-04	3.797E-03	POLB; APEX1
hsa04210	Apoptosis_Homo sapiens_hsa04210	4.190E-03	4.469E-02	LMNA; MCL1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
C00-D49: Neoplasms	Solid tumours	C00-D48	PKM
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1; AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	TTR amyloidosis	E85	TTR
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	TTR
I00-I99: Diseases of the circulatory system	Cardiomyopathy	I42.0	TTR
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
C00-D49: Neoplasms	Cancer	C00-C96	MCL1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Astrantia major

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases