CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; PKM; HSD17B1; NOX4; ALOX15; USP2; TNKS; TNKS2;
Chloride channel	CFTR;
Protein Kinase	GSK3B; SYK; FLT3; CDK6; CSNK2A1;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Oxidoreductase	MAOA; PTGS2; XDH;
Transcription Factor	HIF1A; TP53;
ATP-binding cassette	ABCG2; ABCC1;
Unclassified	NPC1; MAPT; THPO; TTR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Chloride channel	CFTR	Cystic fibrosis transmembrane conductance regulator	P13569	CHEMBL4051
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016579; protein deubiquitination	3.301E-08	1.797E-05	AR, CFTR, ESR1, HIF1A, TNKS, TNKS2, TP53, USP2
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	5.706E-07	1.750E-04	MAPT, NOX4, PTGS2, TP53, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.483E-07	1.908E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	8.903E-07	2.423E-04	AR, CYP19A1, ESR1
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	2.551E-06	5.787E-04	AR, CDK6, CSNK2A1, ESR1, FLT3, HIF1A, PTGS2, SYK, THPO, TSHR
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	6.424E-06	1.260E-03	CYP1A1, HIF1A, NOX4, PKM, PTGS2, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.088E-06	1.378E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.415E-06	1.720E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.123E-05	1.925E-03	ALOX15, GSK3B, HIF1A, MAPT, NOX4, TNKS, TNKS2, TP53
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	1.377E-05	2.324E-03	CYP19A1, CYP1A2, CYP3A4

Showing 1 to 10 of 51 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.933E-10	8.597E-08	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.866E-07	2.129E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.850E-06	1.390E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.739E-05	2.695E-04	CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.991E-04	1.646E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.377E-04	1.842E-03	MAOA, CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.965E-05	4.086E-04	CYP1A2, XDH
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	6.190E-05	6.396E-04	ABCC1, CFTR, ABCG2
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	5.719E-04	3.083E-03	SYK, CSNK2A1, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	1.942E-03	9.262E-03	GSK3B, CSNK2A1, TP53

Showing 1 to 10 of 26 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Xylopia columbiana

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities