Plant Name: Xylopia columbiana
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016579; protein deubiquitination | 3.301E-08 | 1.797E-05 | AR, CFTR, ESR1, HIF1A, TNKS, TNKS2, TP53, USP2 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 1.392E-07 | 5.562E-05 | CFTR, HIF1A, NPC1, PTGS2, SYK, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 5.706E-07 | 1.750E-04 | MAPT, NOX4, PTGS2, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 6.483E-07 | 1.908E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0032501; multicellular organismal process | GO:0060736; prostate gland growth | 8.903E-07 | 2.423E-04 | AR, CYP19A1, ESR1 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 1.655E-06 | 3.960E-04 | CDK6, CFTR, HIF1A, NPC1, PTGS2, SYK, TNKS, TNKS2 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 2.551E-06 | 5.787E-04 | AR, CDK6, CSNK2A1, ESR1, FLT3, HIF1A, PTGS2, SYK, THPO, TSHR |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 6.424E-06 | 1.260E-03 | CYP1A1, HIF1A, NOX4, PKM, PTGS2, TP53 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 7.088E-06 | 1.378E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 9.415E-06 | 1.720E-03 | CYP1A1, CYP1A2, CYP1B1 |
Showing 1 to 10 of 50 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 6.933E-10 | 8.597E-08 | HSD17B1; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.965E-05 | 4.086E-04 | CYP1A2; XDH |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 6.866E-07 | 2.129E-05 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 5.267E-03 | 1.881E-02 | ALOX15; PTGS2 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.739E-05 | 2.695E-04 | CYP1A2; ALOX15; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.991E-04 | 1.646E-03 | CYP1A2; CYP1A1; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.850E-06 | 1.390E-04 | CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.377E-04 | 1.842E-03 | MAOA; CYP1A2; CYP3A4 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.934E-03 | 1.299E-02 | CYP3A4; XDH |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.537E-05 | 4.386E-04 | PKM; MAOA; HSD17B1; CYP1A2; ALOX15; CYP1A1; PTGS2; CYP3A4; CYP19A1; XDH |
Showing 1 to 10 of 43 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | HIV-associated diarrhoea | A09 | CFTR |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Diarrhea | A09, K59.1 | CFTR |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; GSK3B; HIF1A; SYK; TP53; FLT3; FLT3; ACHE; ESR1; ESR1; PTGS2; CSNK2A1 |
Showing 1 to 10 of 158 entries