CMAUP Plant Collective Molecular Activities

Plant Name: Daucus carota

Taxonomic Information:

Plant ID: NPO163
Plant Latin Name: Daucus carota
Taxonomy Genus: Daucus
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 4039
Plant-of-the-World-Online: 841063-1

Used in Medicines:

Country/Region:

Brazil; Turkey; Italy; Lebanon; France; Israel; Algeria; China; Kuwait; Belgium; Jordan; Iraq; Philippines; Indonesia; United States; Thailand; Pakistan; Mexico; Tunisia; India; Greece; South Korea

Traditional Medicine System:

Indian Folk; TCM; Unani; Ayurveda; Siddha

Medicinal Functions:

Anthelmintic; Carminative; Contraceptive; Deobstruent; Diuretic; Emmenagogue; Galactogogue; Ophthalmic; Stimulant

Geographical Distribution:

Brazil; Afghanistan; Italy; Bangladesh; Sudan; Kuwait; Nepal; France; Netherlands; Ireland; Norway; Turkmenistan; Israel; Belarus; Iran; Algeria; Cuba; Turkey; Jordan; Russia; China; Belgium; Germany; Dominican Republic; Iraq; Kazakhstan; Poland; Spain; Lebanon; Ukraine; Finland; Pakistan; Denmark; Philippines; Indonesia; United States; Morocco; Sweden; Thailand; Switzerland; New Zealand; Haiti; Bulgaria; Jamaica; Romania; Albania; Angola; Portugal; Mexico; Tunisia; South Africa; India; Peru; United Kingdom; Austria; Greece; Hungary; South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRK1;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA7; CA14; CA3; CA5B; CA5A; CA6;
Oxidoreductase	PTGS1;
Enzyme_unclassified	ALOX15; ALDH1A1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA; NPC1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRK1	Kappa opioid receptor	P41145	CHEMBL237
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.933E-07	3.992E-04	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.953E-27	6.430E-23	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.874E-06	3.681E-03	CA2, CA9, SLCO1B1, SLCO1B3, TSHR
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	5.365E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.394E-21	2.606E-17	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.173E-19	6.386E-16	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	2.294E-02	CA1, CA2
BP	GO:0032501; multicellular organismal process	GO:0050951; sensory perception of temperature stimulus	3.095E-05	3.064E-02	OPRK1, TRPA1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.349E-26	1.497E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.468E-06	8.149E-05	SLCO1B1, CA2, SLCO1B3, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.316E-05	2.337E-03	CYP2A6, ALDH1A1, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.176E-04	8.813E-03	ALOX15, MAPK1, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.493E-04	1.220E-02	ALOX15, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.383E-03	2.559E-02	CYP2A6, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.043E-03	3.239E-02	TSHR, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.497E-03	3.465E-02	ALOX15, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.083E-03	3.802E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.443E-03	3.822E-02	CYP2A6, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; CA9;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases