Plant Name: Schizolaena hystrix
Taxonomic Information:
Plant ID: NPO16269
Plant Latin Name: Schizolaena hystrix
Taxonomy Genus: Schizolaena
Taxonomy Family: Sarcolaenaceae
Plant External Links:
NCBI TaxonomyDB:
1915033
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 2.071E-04 | 7.515E-01 | ACHE |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 1.681E-02 | 1.000E+00 | LMNA |
| MF | GO:0005488; binding | GO:0043621; protein self-association | 5.584E-03 | 1.000E+00 | ACHE |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 6.203E-03 | 1.000E+00 | ACHE |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.386E-03 | 1.328E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.107E-02 | 1.328E-02 | ACHE |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 8.283E-03 | 1.328E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 8.980E-03 | 1.328E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.395E-02 | 1.395E-02 | LMNA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 9.478E-03 | 1.328E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
