CMAUP Plant Collective Molecular Activities

Plant Name: Broussonetia kazinoki

Taxonomic Information:

Plant ID: NPO16111
Plant Latin Name: Broussonetia kazinoki
Taxonomy Genus: Broussonetia
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 66380
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Medicinal Functions:

Tonic

Geographical Distribution:

South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	MTOR;
Lyase	CA12;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.538E-07	7.704E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.121E-06	2.310E-02	ESR1, ESR2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.300E-06	2.885E-02	CYP1A2, CYP2C19

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.237E-05	2.881E-03	TP53, ESR1, MTOR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.119E-04	4.802E-03	TP53, ESR1, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.328E-04	4.515E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.722E-04	7.005E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.140E-04	7.005E-03	TP53, MTOR
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	8.241E-04	7.005E-03	ESR1, ESR2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.571E-04	7.005E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.255E-03	8.537E-03	TP53, MTOR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.014E-04	7.005E-03	SLCO1B1, SLCO1B3
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.399E-03	8.648E-03	TP53, MTOR
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.550E-03	8.783E-03	ESR1, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	8.063E-03	CYP1A2, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases