CMAUP Plant Collective Molecular Activities

Plant Name: Broussonetia kazinoki

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.538E-07	7.704E-03	ESR1, ESR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	4.237E-05	2.881E-03	TP53; ESR1; MTOR
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	2.119E-04	4.802E-03	TP53; ESR1; MTOR
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.328E-04	4.515E-03	CYP1A2; CYP2C19
hsa05214	Glioma_Homo sapiens_hsa05214	6.722E-04	7.005E-03	TP53; MTOR
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	7.140E-04	7.005E-03	TP53; MTOR
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	8.241E-04	7.005E-03	ESR1; ESR2
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	7.571E-04	7.005E-03	CYP1A2; CYP2C19
hsa05215	Prostate cancer_Homo sapiens_hsa05215	1.255E-03	8.537E-03	TP53; MTOR
hsa04976	Bile secretion_Homo sapiens_hsa04976	8.014E-04	7.005E-03	SLCO1B1; SLCO1B3
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.399E-03	8.648E-03	TP53; MTOR
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	1.550E-03	8.783E-03	ESR1; ESR2
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.067E-03	8.063E-03	CYP1A2; CYP2C19
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	3.886E-03	1.887E-02	THPO; MTOR
hsa03013	RNA transport_Homo sapiens_hsa03013	4.586E-03	2.079E-02	SMN2; SMN1
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.016E-02	4.316E-02	CA12
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	2.997E-03	1.568E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
C00-D49: Neoplasms	Solid tumours	C00-D48	MTOR; TP53
C00-D49: Neoplasms	Solid tumors	NA	MTOR
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
NA: NA	Coronary artery restenosis	NA	MTOR
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
C00-D49: Neoplasms	Cancer	C00-C96	MTOR; ESR1; ESR1; TP53
NA: NA	Gonorrheal vaginitis	NA	ESR1
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Renal cancer	C64	MTOR
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1
NA: NA	Menopausal disorder	NA	ESR1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR
C00-D49: Neoplasms	Bladder cancer	C67	MTOR
C00-D49: Neoplasms	Breast cancer	C50	ESR1; ESR1
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR; MTOR
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR; ESR1
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR
C00-D49: Neoplasms	Prostate cancer	C61	ESR1
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases