CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family C GPCR)	GABBR1;
Enzyme_unclassified	BLM; GLA;
GABA-A receptor	GABRR1;
Transcription Factor	NFKB1;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC6A1; SLC6A11;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
SLC superfamily of solute carriers	SLC6A1	GABA transporter 1	P30531	CHEMBL1903
SLC superfamily of solute carriers	SLC6A11	GABA transporter 3	P48066	CHEMBL5208
Small molecule receptor (family C GPCR)	GABBR1	GABA-B receptor 1	Q9UBS5	CHEMBL2064

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.300E-06	3.847E-02	CYP2C19, CYP3A4
MF	GO:0005215; transporter activity	GO:0005332; gamma-aminobutyric acid:sodium symporter activity	2.121E-06	3.847E-02	SLC6A1, SLC6A11

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.328E-04	5.577E-03	CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.571E-04	1.272E-02	CYP3A4, CYP2C19
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo series	8.370E-03	7.031E-02	GLA
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.998E-04	5.594E-03	GABBR1, NFKB1, TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.270E-04	1.107E-02	GABBR1, GABRR1, TSHR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.067E-03	3.220E-02	LMNA, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	1.686E-07	1.416E-05	GABBR1, GABRR1, SLC6A11, SLC6A1
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	1.312E-03	1.574E-02	GABBR1, GABRR1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	1.494E-02	CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.010E-03	4.676E-02	KMT2A, NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Shorea uliginosa

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities