Plant Name: Shorea uliginosa
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04727 | GABAergic synapse_Homo sapiens_hsa04727 | 1.686E-07 | 1.416E-05 | GABBR1; GABRR1; SLC6A11; SLC6A1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.998E-04 | 5.594E-03 | GABBR1; NFKB1; TSHR |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.328E-04 | 5.577E-03 | CYP3A4; CYP2C19 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 5.270E-04 | 1.107E-02 | GABBR1; GABRR1; TSHR |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 7.571E-04 | 1.272E-02 | CYP3A4; CYP2C19 |
| hsa05032 | Morphine addiction_Homo sapiens_hsa05032 | 1.312E-03 | 1.574E-02 | GABBR1; GABRR1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.067E-03 | 1.494E-02 | CYP3A4; CYP2C19 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 3.220E-02 | LMNA; NFKB1 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 5.010E-03 | 4.676E-02 | KMT2A; NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Myeloma | C90 | SLC6A1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Fabry's disease | E75.2 | GLA |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Convulsions | R56.0 | SLC6A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |