CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; FAAH; TERT; HSD11B1; GFER; HSD17B10; AKR1B10; ALDH1A1;
Lyase	CA2; CA1; CA12; CA9; CA3; CA5B; CA14; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Cysteine protease	CASP1; CASP7;
Toll-like and Il-1 receptors	TLR2;
Unclassified	NPC1; RAB9A; FABP3; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.139E-07	1.664E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	3.067E-07	2.303E-04	ESR2, NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	1.040E-06	7.079E-04	ESR2, NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.754E-06	1.061E-03	ESR2, NR1H4, PPARA, PPARD, PPARG, RORC
BP	GO:0065007; biological regulation	GO:0055088; lipid homeostasis	3.478E-06	1.942E-03	FABP3, FABP4, NPC1, NR1H4, PPARG
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.328E-06	2.207E-03	NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.215E-05	4.812E-03	FABP3, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.272E-05	4.860E-03	AKR1B10, CYP1A2, HSD11B1, NPC1, NR1H4, PPARD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.317E-05	4.860E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.317E-05	4.860E-03	GPBAR1, NR1H4

Showing 1 to 10 of 24 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.579E-27	5.760E-25	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.860E-03	5.619E-02	CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9.829E-03	5.619E-02	HSD11B1, CYP1A2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	4.685E-04	8.902E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	8.717E-11	3.312E-09	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.009E-03	1.534E-02	CA2, CA4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.318E-03	5.619E-02	CA2, NR1H4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.948E-04	4.935E-03	CASP7, CASP1, TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.444E-03	1.829E-02	PTPN1, PPARA, PTPRF
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.035E-02	5.619E-02	CASP7, CASP1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Achillea lycaonica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities